CD3 antibody (CD3)

Details for Product anti-CD3 Antibody No. ABIN567797, Supplier: Log in to see
Antigen
  • CD3
  • CD3d molecule, delta (CD3-TCR complex)
  • CD3e molecule, epsilon (CD3-TCR complex)
  • DNA segment, Chr 9, MRC UK Mouse Genome Centre 45 expressed
  • CD3D
  • CD3E
  • D9Mgc45e
Reactivity
Human
795
281
82
43
40
33
30
16
15
14
13
11
10
8
5
5
5
5
5
5
5
5
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5
5
5
5
5
5
3
2
1
1
Host
Hamster
889
179
62
42
22
1
Clonality (Clone)
Monoclonal ()
Conjugate
This CD3 antibody is un-conjugated
158
120
93
65
30
23
22
21
21
20
16
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13
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12
11
8
8
8
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2
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2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunoprecipitation (IP), Western Blotting (WB)
954
261
212
150
126
122
111
110
77
48
19
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7
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4
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4
3
3
3
3
3
3
3
2
2
2
2
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen Human T3 cells.
Clone HAM25-1352
Isotype IgG
Specificity This antibody reacts with CD3 epsilon (23 kDa) on Western blotting.
Purification Protein-A Agarose Chromatography of hybridoma supernatant.
Alternative Name CD3 (CD3 Antibody Abstract)
Background The antigen receptor of the T lymphocyte consists of two variable T-cell receptor chains (either TCR-apha, TCR-beta or TCR-gamma, TCR-delta) noncovalently linked to four different invariant membrane proteins ((CD3-γ , CD3-δ , CD3-ε , and the CD3-ζ homodimer). The CD3 genes are expressed early in thymocyte development, preceding the rearrangement and expression of the T-cell receptor genes. The CD3 epsilon polypeptide contributes to the cell surface display as well as to the signal transduction properties of the T-cell antigen receptor complex. Intriguingly, the distribution of CD3 epsilon is not restricted to T cells, since activated mouse, human, and avian natural killer (NK) cells do express intracytoplasmic CD3 epsilon polypeptides. CD3 epsilon is also present in the cytoplasm of fetal thymic T/NK bipotential progenitor cells, suggesting that it constitutes a component of the NK differentiation program.Synonyms: T-cell surface antigen T3/Leu-4, T-cell surface glycoprotein CD3, T3/Leu-4
Gene ID 916
NCBI Accession NP_000724
UniProt P07766
Research Area Immunology, Adaptive Immunity, Hematopoietic Progenitors, Hematopoietic Stem Cells, CD Antigens, Surface Receptors of Immune Cells
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS, pH 7.2 containing 50 % Glycerol without preservatives.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.
Supplier Images
Western Blotting (WB) image for anti-CD3 (CD3) antibody (ABIN567797) anti-CD3 (CD3) antibody
Western Blotting (WB) image for anti-CD3 (CD3) antibody (ABIN567797) anti-CD3 (CD3) antibody (Image 2)
Background publications Werlen, Hausmann, Naeher, Palmer: "Signaling life and death in the thymus: timing is everything." in: Science (New York, N.Y.), Vol. 299, Issue 5614, pp. 1859-63, 2003 (PubMed).

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