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Casein Kinase 2, alpha 1 Polypeptide (CSNK2A1) (pThr360), (pSer362) antibody

Details for Product No. ABIN616048
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Antigen
Synonyms CSNK2A1, csnk2a1, CK2A, CK2, Ck2a, BmCK2a, Ckiialpha, CK-II, CK2A1, CKII, CSNK2A3, Csnk2a1-rs4, ck2a1, CK2A2, 1110035J23Rik, C77789
Epitope
pThr360, pSer362
(9), (8), (7), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(107), (38), (34), (13), (12), (8), (2), (2), (1), (1), (1), (1)
Host
Rabbit
(85), (23)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(95), (37), (24), (18), (17), (10), (6), (3), (2), (1), (1)
Pubmed 4 references available
Quantity 50 µL
Shipping to United States (Change)
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Catalog No. ABIN616048
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Immunogen Peptide sequence around phosphorylation site of Threonine 360/Serine 362
Sequence V-P-T(p)-P-S(p)-P-L
Specificity This antibody detects endogenous level of CK2 only when phosphorylated at thronine 360. Species Reactivity: Tested: Human, Mouse, Rat
Purification Affinity Chromatography using epitope-specific peptide
Alternative Name Casein kinase II subunit alpha
Background Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. Participates in Wnt signaling. CK2 phosphorylates 'Ser-392' of p53/TP53 following UV irradiation.
Alternate names: CK II alpha, CK2A1, CSNK2A1
Molecular Weight 42 kDa
Gene ID 1457
NCBI Accession NP_001886
UniProt P68400
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% Sodium Azide and 50% Glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C.
Expiry Date 12 months
Background publications Niefind, Guerra, Ermakowa et al.: "Crystallization and preliminary characterization of crystals of human protein kinase CK2." in: Acta crystallographica. Section D, Biological crystallography, Vol. 56, Issue Pt 12, pp. 1680-4, 2001 (PubMed).

Keller, Zeng, Wang et al.: "A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1." in: Molecular cell, Vol. 7, Issue 2, pp. 283-92, 2001 (PubMed).

Keller, Lu: "p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex." in: The Journal of biological chemistry, Vol. 277, Issue 51, pp. 50206-13, 2002 (PubMed).

Trembley, Tatsumi, Sakashita et al.: "Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation." in: Molecular and cellular biology, Vol. 25, Issue 4, pp. 1446-57, 2005 (PubMed).

Validation Images
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