Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Purpose
Rabbit Anti-Human TIMP-1
Specificity
Ds-PB-01963 reacts with native and denatured TIMP-1, as well as TIMP-1 in and out of enzyme/inhibitor complex. This antibody is not neutralizing. TIMP-1 is expressed by a wide range of cells including microvascular endothelial cells, smooth muscle cells, mesangial cells and some fibroblasts. TIMP-1 inhibits matrix metalloproteinase activity by forming complexes via reversible non covalent binding. It is reported to be involved in the control of angiogenesis and tumour growth.
Supplied as 100 µg of purified antibody. It is reconstituted with 100 µl of sterile PBS. Its final concentration is 1.0 mg/ml. Please avoid freeze-thaw cycles.