M. Tuberculosis antibody

Antigen: M. Tuberculosis

Host: Rabbit

Catalog no.: ABIN648081

Additional Information

Characteristics: Rabbit Anti-M. tuberculosis

Immunogen: Purified PPD

Isotype: IgG  (Matching secondary antibodies)

Description: The small Ras-related protein Ran, also called TC4, is a 24 kDa, nuclear localized GTPase implicated in a diverse array of cellular processes including DNA replication, entry into and exit from mitosis and the transport of RNA and proteins through the nuclear pore complex. Like Ras, active Ran GTP and inactive Ran GDP levels are tightly regulated by guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). The abundant GEF, RCC1 (regulator of chromosome condensation 1), increases the rate at which Ran exchanges GDP for GTP. Ran GAP1 opposes the effects of RCC1 by increasing the rate at which Ran hydrolyzes GTP to GDP. A 23 kDa protein designated Ran BP1 has no intrinsic GAP activity, and functions as a GEF inhibitor deactivating RCC1 and thereby indirectly increasing the ratio of Ran GDP to Ran GTP. The 358 kDa protein Ran BP2 has been proposed as the Ran GTP docking site at the periphery of the nuclear pore complex.

Specificity: Minimum of 2 major M. tuberculosis bands by immunoelectrophoresis (gamma and beta). Has not been absorbed and may react with related microorganisms. Reactive with other Mycobacteria species including M. avium, M. phlei, and M. parafortuitum. Crossreactive with Rhodacoccus sp. Antibody is non-reactive with E. coli K12, Salmonella typhimurium, Pseudomonas aeruginosa, Streptococcus (group B), Candida albicans and Neisseria meningitidis.

Application Details

Concentration: 4-5 mg/ml (OD280nm, E^0.1% = 1.4)

Purification: Purified

Buffer: 0.01M PBS, pH 7.2.This

Preservative: 0.1% Sodium azide

Storage: Short-term (up to 6 months) store at 2-8°C. Long term, aliquot and store at -20°C. Centrifuge before opening to ensure complete recovery of vial contents. Please avoid freeze-thaw cycles.

Restrictions: For Research Use only