Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

E2F1 antibody (His357)

This Rabbit Polyclonal antibody specifically detects E2F1 in DB. It exhibits reactivity toward Human.
Catalog No. ABIN650836

Quick Overview for E2F1 antibody (His357) (ABIN650836)

Target

See all E2F1 Antibodies
E2F1 (E2F Transcription Factor 1 (E2F1))

Reactivity

  • 203
  • 101
  • 55
  • 6
  • 6
  • 6
  • 5
  • 5
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
Human

Host

  • 206
  • 13
  • 2
Rabbit

Clonality

  • 193
  • 28
Polyclonal

Conjugate

  • 101
  • 15
  • 14
  • 11
  • 8
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
This E2F1 antibody is un-conjugated

Application

  • 187
  • 94
  • 66
  • 66
  • 51
  • 28
  • 28
  • 22
  • 19
  • 18
  • 17
  • 17
  • 6
  • 2
  • 1
  • 1
Dot Blot (DB)

Clone

RB07916
  • Binding Specificity

    • 25
    • 24
    • 19
    • 15
    • 15
    • 10
    • 8
    • 8
    • 8
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    His357

    Purification

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This E2F1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding H357 of human E2F1.

    Isotype

    Ig Fraction
  • Application Notes

    DB: 1:500

    Restrictions

    For Research Use only
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C,-20 °C

    Storage Comment

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    Expiry Date

    6 months
  • Target

    E2F1 (E2F Transcription Factor 1 (E2F1))

    Alternative Name

    E2F1

    Background

    The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.

    Molecular Weight

    46920

    Gene ID

    1869

    NCBI Accession

    NP_005216

    UniProt

    Q01094

    Pathways

    p53 Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Autophagy
You are here:
Chat with us!