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Actin-Like 6B (ACTL6B) (AA 42-70), (N-Term) antibody

Details for Product No. ABIN651520, Supplier: Log in to see
Antigen
  • MGC110167
  • zgc:110167
  • ACTL6
  • BAF53B
  • Actl6
  • ArpNa
  • Baf53b
Epitope
AA 42-70, N-Term
19
14
3
2
2
1
1
1
1
Reactivity
Human
37
6
6
2
Host
Rabbit
34
3
2
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
33
22
22
16
3
2
1
1
1
Supplier
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Immunogen This ACTL6B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 AA from the N-terminal region of human ACTL6B.
Clone RB26766
Isotype Ig
Specificity This ACTL6B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-80 amino acids from the N-terminal region of human ACTL6B.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ACTL6B (ACTL6B Antibody Abstract)
Background ACTL6B is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila, the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.
Synonyms: BRG1-associated factor 53B, BAF53B, ArpNalpha, Actin-related protein Baf53b, 53 kDa BRG1-associated factor B, Actin-like protein 6B,BAF53B, ACTL6, ACTL6B
Molecular Weight 46877 DA
Gene ID 51412
NCBI Accession NP_057272
UniProt O94805
Research Area Translation Factors, Signaling, Chromatin, Neurology, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:50-100, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Actin-Like 6B (ACTL6B) (AA 42-70), (N-Term) antibody (ABIN651520) ACTL6B Antibody (N-term) (ABIN651520) western blot analysis in NCI-H460,HepG2 cell li...
Immunohistochemistry (IHC) image for anti-Actin-Like 6B (ACTL6B) (AA 42-70), (N-Term) antibody (ABIN651520) ACTL6B Antibody (N-term) (ABIN651520) immunohistochemistry analysis in formalin fixed...
Flow Cytometry (FACS) image for anti-Actin-Like 6B (ACTL6B) (AA 42-70), (N-Term) antibody (ABIN651520) ACTL6B Antibody (N-term) (ABIN651520) flow cytometric analysis of HepG2 cells (bottom...
Background publications Oma, Nishimori, Harata: "The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP." in: Biochemical and biophysical research communications, Vol. 301, Issue 2, pp. 521-8, 2003 (PubMed).

Kuroda, Oma, Nishimori et al.: "Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex." in: Biochemical and biophysical research communications, Vol. 299, Issue 2, pp. 328-34, 2002 (PubMed).

Olave, Wang, Xue et al.: "Identification of a polymorphic, neuron-specific chromatin remodeling complex." in: Genes & development, Vol. 16, Issue 19, pp. 2509-17, 2002 (PubMed).