Kallikrein 6 (KLK6) (N-Term) antibody

Antigen: Kallikrein 6 (KLK6)

Synonyms: hK6, Bssp, Klk7, SP59, ZYME, PRSS9, PRSS18, MGC9355, NEUROSIN, rk8, KLK8, Klk6, rGK-8, Klk1c8, klk6, Prss9

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN652195

Additional Information

Gene ID: 5653

UniProt: Q92876

Immunogen: This KLK6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6~35 amino acids from the N-terminal region of human KLK6.

Isotype: Ig

Description: Other names: Protease M, Neurosin, Zyme, SP59,

Characteristics: Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This Kallikrein 6 Antibody antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6~35 amino acids from the N-terminal region of human KLK6.

Molecular Weight: 26856 DA

Comments:

Background: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The KLK6 enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease.

Application Details

Application Notes: The suggested dilution is: ELISA~~1:1,000 Western blotting~~1:50~100

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.Preca

Research Area: Neurology, Cell Structure

Restrictions: For Research Use only

Images

Western blot analysis of KLK6 (arrow) using rabbit polyclonal KLK6 Antibody (A13) (ABIN652195). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the KLK6 gene.

Kallikrein 6(KLK6) Antibody (N-term) (ABIN652195)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Kallikrein 6(KLK6) Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Publications

Product: Sauter, Lininger, Magklara et al.: "Association of kallikrein expression in nipple aspirate fluid with breast cancer risk." in: International journal of cancer. Journal international du cancer, Vol. 108, Issue 4, pp. 588-91, 2003 (PubMed).

Pampalakis, Kurlender, Diamandis et al.: "Cloning and characterization of novel isoforms of the human kallikrein 6 gene." in: Biochemical and biophysical research communications, Vol. 320, Issue 1, pp. 54-61, 2004 (PubMed).

Ghosh, Grass, Soosaipillai et al.: "Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells." in: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, Vol. 25, Issue 4, pp. 193-9, 2004 (PubMed).