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Vitronectin antibody (VTN) (AA 65-93)

Details for Product anti-VTN Antibody No. ABIN652347, Supplier: Log in to see
Antigen
  • VTN
  • DKFZp470F0511
  • LOC100228142
  • vtn
  • zgc:112277
  • V75
  • VN
  • VNT
  • AI256434
  • Vn
  • Aa1018
Epitope
AA 65-93, N-Term
19
13
9
9
8
8
6
6
5
4
4
4
3
1
1
1
1
1
1
1
1
1
Reactivity
Human
242
67
26
12
4
2
2
2
2
1
Host
Rabbit
162
112
15
2
1
Clonality (Clone)
Polyclonal ()
Conjugate
This Vitronectin antibody is un-conjugated
13
12
10
4
4
4
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
220
171
69
31
30
18
18
16
15
11
11
10
5
5
3
3
3
2
2
2
2
2
2
1
1
1
Supplier
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Immunogen This VTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-93 AA from the N-terminal region of human VTN.
Clone RB17843
Isotype Ig
Specificity This VTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72~101 amino acids from the N-terminal region of human VTN.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name VTN (VTN Antibody Abstract)
Background VTN is a member of the pexin family. This protein is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. The protein is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond.
Synonyms: Vitronectin, Serum-spreading factor, S-protein, V75, Vitronectin V65 subunit, Vitronectin V10 subunit, Somatomedin-B , VTN
Pathways: Focal adhesion, ECM-receptor interaction
Molecular Weight 54,306 Da
Gene ID 7448
UniProt P04004
Research Area Signaling, Cancer
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.34 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Vitronectin antibody (VTN) (AA 65-93) (ABIN652347) Western blot analysis of VTN Antibody (N-term) (ABIN652347) in NCI-H460 cell line lys...
Immunohistochemistry (IHC) image for anti-Vitronectin antibody (VTN) (AA 65-93) (ABIN652347) Formalin-fixed and paraffin-embedded human lung carcinoma reacted with VTN Antibody (...
Flow Cytometry (FACS) image for anti-Vitronectin antibody (VTN) (AA 65-93) (ABIN652347) VTN Antibody (N-term) (ABIN652347) flow cytometric analysis of NCI-H460 cells (bottom...
Product cited in: Lamar, Stern, Liu et al.: "The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 37, pp. E2441-50, 2012 (PubMed).

Background publications Sigurdardottir, Wiman: "Identification of a PAI-1 binding site in vitronectin." in: Biochimica et biophysica acta, Vol. 1208, Issue 1, pp. 104-10, 1994 (PubMed).

Jenne, Stanley: "Molecular cloning of S-protein, a link between complement, coagulation and cell-substrate adhesion." in: The EMBO journal, Vol. 4, Issue 12, pp. 3153-7, 1986 (PubMed).

Seiffert, Loskutoff: "Evidence that type 1 plasminogen activator inhibitor binds to the somatomedin B domain of vitronectin." in: The Journal of biological chemistry, Vol. 266, Issue 5, pp. 2824-30, 1991 (PubMed).