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Details for Product No. ABIN653331

T-Box 1 (TBX1) (C-Term), (AA 327-356) antibody

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Synonyms DGS, TGA, CAFS, CTHM, DGCR, DORV, VCFS, TBX1C, 3222402J11Rik, C85531, N4WBP3, TBX1, mp:zf637-3-000616, zgc:136724, dgs, tga, cafs, cthm, dgcr, dorv, vcfs, tbx1c, xtbx1
»Alternatives C-Term, AA 327-356
»Alternatives Human
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
Pubmed 4 references available
Catalog no. ABIN653331
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This TBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 327-356 AA from the C-terminal region of human TBX1.
Clone RB22154
Isotype Ig
Specificity This TBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 334~364 amino acids from the C-terminal region of human TBX1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name TBX1
Background TBX1 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Synonyms: Testis-specific T-box protein, T-box transcription factor TBX1, T-box protein 1, TBX1
Molecular Weight 43133 DA
Gene ID 6899
UniProt O43435
Research Area Transcription Factors, Signaling, Neurology
Application Notes Recommend dilutions: WB : 1:1000,IF : 1:10-50,IHC : 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Yamagishi, Maeda, Hu et al.: "Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer." in: Genes & development, Vol. 17, Issue 2, pp. 269-81, 2003 (PubMed).

Shalaby, Presneau, Idowu et al.: "Analysis of the fibroblastic growth factor receptor-RAS/RAF/MEK/ERK-ETS2/brachyury signalling pathway in chordomas." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 22, Issue 8, pp. 996-1005, 2009 (PubMed).

Beaujard, Chantot, Dubois et al.: "Atypical deletion of 22q11.2: detection using the FISH TBX1 probe and molecular characterization with high-density SNP arrays." in: European journal of medical genetics, Vol. 52, Issue 5, pp. 321-7, 2009 (PubMed).

Heike, Starr, Rieder et al.: "Single nucleotide polymorphism discovery in TBX1 in individuals with and without 22q11.2 deletion syndrome." in: Birth defects research. Part A, Clinical and molecular teratology, Vol. 88, Issue 1, pp. 54-63, 2010 (PubMed).

Alternatives for antigen "T-Box 1 (TBX1)", type "Antibodies"
Hosts (35), (3)
Reactivities (36), (15), (14), (12), (12), (12), (12)
Applications (28), (19), (10), (10), (6), (6), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (2), (2), (1), (1), (1), (1), (1), (1)