TM173 (C-Term), (AA 311-340) antibody

Details for Product No. ABIN653703
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Antigen
Epitope
C-Term, AA 311-340
(1), (1)
Reactivity
Human, Mouse (Murine)
(1), (1)
Host
Rabbit
(1)
Clonality (Clone)
Polyclonal ()
Application
Western Blotting (WB), Flow Cytometry (FACS)
(1), (1)
Pubmed 2 references available
Catalog no. ABIN653703
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This TM173 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 311-340 AA from the C-terminal region of human TM173.
Clone RB24462
Isotype Ig
Specificity This TM173 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 318~348 amino acids from the C-terminal region of human TM173.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Background Acts as a facilitator of innate immune signaling. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
Synonyms: Mediator of IRF3 activation, hMITA, Stimulator of interferon genes protein, hSTING, Transmembrane protein 173, STING, MITA, TMEM173
Molecular Weight 42193 DA
Gene ID 340061
UniProt Q86WV6
Research Area Apoptosis/Necrosis, Cell Structure
Application Notes WB = 1:1000, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-TM173 (C-Term), (AA 311-340) antibody Western blot analysis of TM173 Antibody (C-term) (ABIN653703) in mouse spleen tissue lysates (35 µg/lane). TM173 (arrow) was detected using the purified polyclonal antibody.
anti-TM173 (C-Term), (AA 311-340) antibody (2) TM173 Antibody (C-term) (ABIN653703) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Zhong, Zhang, Lei et al.: "The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA." in: Immunity, Vol. 30, Issue 3, pp. 397-407, 2009 (PubMed).

Sun, Li, Chen et al.: "ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 21, pp. 8653-8, 2009 (PubMed).

Hosts (1)
Reactivities (1), (1)
Applications (1), (1)
Epitopes (1), (1)
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