This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This IGF2BP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 508-534 amino acids from the C-terminal region of human IGF2BP1.
Yang, Xu, Lu, Li, Sun, Guo, Xue, Guan: "Quantitative Analysis of Differential Proteome Expression in Bladder Cancer vs. Normal Bladder Cells Using SILAC Method." in: PLoS ONE, Vol. 10, Issue 7, pp. e0134727, (2015) (PubMed).
Target
IGF2BP1
(Insulin-Like Growth Factor 2 mRNA Binding Protein 1 (IGF2BP1))
IGF2BP1 is a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene.