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Details for Product No. ABIN654683

H2A Histone Family, Member Y2 (H2AFY2) (N-Term), (AA 11-39) antibody

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Antigen
Synonyms macroH2A2, RGD1561371, MGC69037, MGC130768, macroh2a2, im:6898017, wu:fa14g05, zgc:114051
Epitope
»Alternatives N-Term, AA 11-39
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB), Flow Cytometry (FACS)
Pubmed 3 references available
Catalog no. ABIN654683
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This H2AFY2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-39 AA from the N-terminal region of human H2AFY2.
Clone RB28554
Isotype Ig
Specificity This H2AFY2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-43 amino acids from the N-terminal region of human H2AFY2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name H2AFY2
Background Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
Synonyms: Core histone macro-H2A.2,H2AFY2,MACROH2A2
Molecular Weight 40058 DA
Gene ID 55506
UniProt Q9P0M6, NP_061119.1
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,FC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Deloukas, Earthrowl, Grafham et al.: "The DNA sequence and comparative analysis of human chromosome 10." in: Nature, Vol. 429, Issue 6990, pp. 375-81, 2004 (PubMed).

Sporn, Kustatscher, Hothorn et al.: "Histone macroH2A isoforms predict the risk of lung cancer recurrence." in: Oncogene, Vol. 28, Issue 38, pp. 3423-8, 2009 (PubMed).

Xu, Zheng, Isaacs et al.: "Inherited genetic variant predisposes to aggressive but not indolent prostate cancer." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 5, pp. 2136-40, 2010 (PubMed).

Alternatives for antigen "H2A Histone Family, Member Y2 (H2AFY2)", type "Antibodies"
Hosts (15)
Reactivities (12), (5), (2), (1)
Applications (15), (4), (3), (2), (1), (1)
Epitopes (3), (3), (2), (2), (1), (1), (1)
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