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Details for Product No. ABIN655083

Inhibin, beta B (INHBB) (C-Term), (AA 369-397) antibody

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Antigen
Synonyms actbb, actbetaB, inhibin
Epitope
»Alternatives C-Term, AA 369-397
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 1 reference available
Catalog no. ABIN655083
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This INHBB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 369-397 AA from the C-terminal region of human INHBB.
Clone RB23814
Isotype Ig
Specificity This INHBB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 376-404 amino acids from the C-terminal region of human INHBB.
Predicted Reactivity Cow (Bovine),Chicken,Pig (Porcine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name INHBB
Background The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
Synonyms: Inhibin beta B chain,INHBB,
Molecular Weight 45122 DA
Gene ID 3625
UniProt P09529, NP_002184.2
Research Area Cell Signaling, Protein Modifications, Cell Cycle, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Canzian, Cox, Setiawan et al.: "Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium." in: Human molecular genetics, Vol. 19, Issue 19, pp. 3873-84, 2010 (PubMed).

Alternatives for antigen "Inhibin, beta B (INHBB)", type "Antibodies"
Hosts (50), (4)
Reactivities (35), (28), (24), (17), (12), (12), (12), (8), (4)
Applications (39), (38), (17), (15), (12), (10), (10), (2), (2), (1), (1), (1)
Conjugates (11), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1)
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