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Autophagy Related 4D, Cysteine Peptidase (ATG4D) (AA 42-71), (N-Term) antibody

Details for Product No. ABIN655395, Supplier: Log in to see
Antigen
  • 9830134P12Rik
  • APG4-D
  • apg4d
  • APG4D
  • Apg4d
  • Atg4dl
  • AUTL4
  • Autl4
Epitope
AA 42-71, N-Term
32
15
14
13
13
13
11
8
3
3
3
2
1
1
1
Reactivity
Mouse (Murine)
132
50
38
3
3
1
1
1
Host
Rabbit
101
17
15
2
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
7
7
7
5
5
5
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
99
52
23
22
17
16
2
2
Supplier
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Immunogen This ATG4D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-71 AA from the N-terminal region of human ATG4D.
Clone RB14788
Isotype Ig
Specificity This ATG4D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-79 amino acids from the N-terminal region of human ATG4D.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name ATG4D (ATG4D Antibody Abstract)
Background Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases.
Synonyms: ATG4D,Cysteine protease ATG4D,APG4D, AUTL4
Molecular Weight 52922 DA
Gene ID 84971
NCBI Accession NP_116274
UniProt Q86TL0
Research Area Autophagy, Cell Structure, Metabolism
Application Notes IF = 1:200, WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Autophagy Related 4D, Cysteine Peptidase (ATG4D) (AA 42-71), (N-Term) antibody (ABIN655395) ATG4D Antibody (N-term) (ABIN655395) immunohistochemistry analysis in formalin fixed ...
Background publications Betin, Lane: "Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis." in: Journal of cell science, Vol. 122, Issue Pt 14, pp. 2554-66, 2009

Lamesch, Li, Milstein, Fan, Hao, Szabo, Hu, Venkatesan, Bethel, Martin, Rogers, Lawlor, McLaren, Dricot, Borick, Cusick, Vandenhaute, Dunham, Hill, Vidal: "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes." in: Genomics, Vol. 89, Issue 3, pp. 307-15, 2007

Mariño, Uría, Puente, Quesada, Bordallo, López-Otín: "Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy." in: The Journal of biological chemistry, Vol. 278, Issue 6, pp. 3671-8, 2003