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Mediator Complex Subunit 6 (MED6) (C-Term), (AA 217-246) antibody

Details for Product No. ABIN656028
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Antigen
Synonyms 1500012F11Rik, AU019660, AV213303, NY-REN-28
Epitope
C-Term, AA 217-246
(8), (8), (8), (8), (5), (3), (2), (1), (1)
Reactivity
Human
(36), (5), (4), (2), (2), (2)
Host
Rabbit
(29), (7)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(33), (22), (4), (2), (2)
Pubmed 5 references available
Quantity 400 µL
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Catalog No. ABIN656028
291.50 $
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This MED6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-246 AA from the C-terminal region of human MED6.
Clone RB20184
Isotype Ig
Specificity This MED6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 214-246 amino acids from the C-terminal region of human MED6.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name MED6
Background Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Synonyms: MED6,Mediator of RNA polymerase II transcription subunit 6,ARC33
Molecular Weight 28425 DA
Gene ID 10001
UniProt NP_005457.2, O75586
Research Area Translation Factors, Signaling, Protein Modifications, Transcription Factors, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.29 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Mediator Complex Subunit 6 (MED6) (C-Term), (AA 217-246) antibody MED6 Antibody (C-term) (ABIN656028) western blot analysis in HepG2 cell line lysates (35 µg/lane). This demonstrates the MED6 antibody detected the MED6 protein (arrow).
Background publications Sato, Tomomori-Sato, Banks et al.: "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex." in: The Journal of biological chemistry, Vol. 278, Issue 50, pp. 49671-4, 2003 (PubMed).

Tomomori-Sato, Sato, Parmely et al.: "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2." in: The Journal of biological chemistry, Vol. 279, Issue 7, pp. 5846-51, 2004 (PubMed).

Yang, DeBeaumont, Zhou et al.: "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 8, pp. 2339-44, 2004 (PubMed).

Sato, Tomomori-Sato, Parmely et al.: "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology." in: Molecular cell, Vol. 14, Issue 5, pp. 685-91, 2004 (PubMed).

Pavri, Lewis, Kim et al.: "PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator." in: Molecular cell, Vol. 18, Issue 1, pp. 83-96, 2005 (PubMed).

Hosts (29), (7)
Reactivities (36), (5), (4), (2), (2), (2)
Applications (33), (22), (4), (2), (2)
Conjugates (2), (2), (2), (2), (2), (2)
Epitopes (8), (8), (8), (8), (5), (3), (2), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN656028
291.50 $
Plus shipping costs $45.00
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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