Aldo-keto Reductase Family 1, Member C2 (AKR1C2) (C-Term) antibody

Antigen: Aldo-keto Reductase Family 1, Member C2 (AKR1C2)

Synonyms: DD, DD2, BABP, DDH2, HBAB, HAKRD, MCDR2, FLJ53800, AKR1C-pseudo, MGC145674

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN656180

Additional Information

Alternative name: AKR1C2

Gene ID: 1646

UniProt: P52895, NP_995317.1

Immunogen: This AKR1C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 295-323 amino acids from the C-terminal region of human AKR1C2.

Isotype: Ig

Description: Other names: AKR1C2,Aldo-keto reductase family 1 member C2,DDH2

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This AKR1C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 295-323 amino acids from the C-terminal region of human AKR1C2.

Molecular Weight: 36735 DA

Comments:

Background: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: AKR1C2 Antibody (C-term) can be refrigerated at 2-8°C for up to 6 months. For long term storage, place the at -20°C.

Research Area: Signaling, Protein Modifications, Metabolism, Cell Structure

Restrictions: For Research Use only

Images

AKR1C2 Antibody (C-term) (ABIN656180) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of AKR1C2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Publications

Product: Wang, Chorley, Pittman et al.: "Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer." in: PLoS ONE, Vol. 5, Issue 8, pp. e11934, 2010 (PubMed).