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HIST1H2AA antibody (Histone Cluster 1, H2aa) (AA 1-30)

Details for Product anti-HIST1H2AA Antibody No. ABIN656333, Supplier: Log in to see
Antigen
  • bA317E16.2
  • H2AA
  • H2AFR
Epitope
AA 1-30, N-Term
17
16
4
Reactivity
Human
22
1
Host
Rabbit
23
Clonality (Clone)
Polyclonal ()
Conjugate
This HIST1H2AA antibody is un-conjugated
3
3
2
2
2
2
Application
Western Blotting (WB)
18
18
1
1
1
1
1
1
Supplier
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Immunogen This HIST1H2AA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human HIST1H2AA.
Clone RB31378
Isotype Ig
Specificity This HIST1H2AA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human HIST1H2AA.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name HIST1H2AA
Background Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element.
Synonyms: HIST1H2AA,Histone H2A type 1-A,H2AFR
Molecular Weight 14234 DA
Gene ID 221613
NCBI Accession NP_734466
UniProt Q96QV6
Research Area Ubiquitin-related antibodies, Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment HIST1H2AA Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-HIST1H2AA antibody (Histone Cluster 1, H2aa) (AA 1-30) (ABIN656333) HIST1H2AA Antibody (N-term) (ABIN656333) western blot analysis in CEM cell line lysat...
Background publications Lamesch, Li, Milstein, Fan, Hao, Szabo, Hu, Venkatesan, Bethel, Martin, Rogers, Lawlor, McLaren, Dricot, Borick, Cusick, Vandenhaute, Dunham, Hill, Vidal: "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes." in: Genomics, Vol. 89, Issue 3, pp. 307-15, 2007 (PubMed).

Bergink, Salomons, Hoogstraten, Groothuis, de Waard, Wu, Yuan, Citterio, Houtsmuller, Neefjes, Hoeijmakers, Vermeulen, Dantuma: "DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A." in: Genes & development, Vol. 20, Issue 10, pp. 1343-52, 2006 (PubMed).

Cao, Tsukada, Zhang: "Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing." in: Molecular cell, Vol. 20, Issue 6, pp. 845-54, 2005 (PubMed).

Hagiwara, Hidaka, Yamada: "Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes." in: Biochemistry, Vol. 44, Issue 15, pp. 5827-34, 2005 (PubMed).

Wang, Wang, Erdjument-Bromage, Vidal, Tempst, Jones, Zhang: "Role of histone H2A ubiquitination in Polycomb silencing." in: Nature, Vol. 431, Issue 7010, pp. 873-8, 2004 (PubMed).