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IREB2 antibody (Iron-Responsive Element Binding Protein 2) (AA 201-230)

Details for Product anti-IREB2 Antibody No. ABIN656586, Supplier: Log in to see
Antigen
  • ACO3
  • D9Ertd85e
  • DKFZp468N047
  • im:7153062
  • IREB2
  • IREBP2
  • Irp2
  • IRP2
  • IRP2AD
Epitope
AA 201-230, Center
33
22
18
17
14
10
6
3
3
1
1
1
Reactivity
Human
71
42
11
2
2
1
1
1
1
1
Host
Rabbit
72
18
10
Clonality (Clone)
Polyclonal ()
Conjugate
This IREB2 antibody is un-conjugated
6
5
5
4
4
4
3
3
3
2
2
2
2
2
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
95
39
31
17
16
16
14
3
2
1
Supplier
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Immunogen This IREB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 201-230 AA from the Central region of human IREB2.
Clone RB30212
Isotype Ig
Specificity This IREB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-238 amino acids from the Central region of human IREB2.
Predicted Reactivity Mouse (Murine),Pig (Porcine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name IREB2 (IREB2 Antibody Abstract)
Background IREB2 is a RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
Synonyms: Iron-responsive element-binding protein 2,IREB2,
Molecular Weight 105045 DA
Gene ID 3658
NCBI Accession NP_004127
UniProt P48200
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Chromatin, Signaling, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.35 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment IREB2 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Immunohistochemistry (IHC) image for anti-IREB2 antibody (Iron-Responsive Element Binding Protein 2) (AA 201-230) (ABIN656586) IREB2 Antibody (Center) (ABIN656586) immunohistochemistry analysis in formalin fixed ...
Background publications Ucisik-Akkaya, Davis, Do, Morrison, Stemmer, Amadio, Dorak: "Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection." in: Molecular human reproduction, Vol. 16, Issue 10, pp. 770-7, 2010 (PubMed).

Hansen, Xiao, Rice, Bracci, Wrensch, Sison, Chang, Smirnov, Patoka, Seldin, Quesenberry, Kelsey, Wiencke: "Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans." in: Human molecular genetics, Vol. 19, Issue 18, pp. 3652-61, 2010 (PubMed).

Cho, Boutaoui, Klanderman, Sylvia, Ziniti, Hersh, DeMeo, Hunninghake, Litonjua, Sparrow, Lange, Won, Murphy, Beaty, Regan, Make, Hokanson, Crapo, Kong, Anderson, Tal-Singer, Lomas, Bakke, Gulsvik, Pillai, Silverman: "Variants in FAM13A are associated with chronic obstructive pulmonary disease." in: Nature genetics, Vol. 42, Issue 3, pp. 200-2, 2010 (PubMed).

Salahudeen, Thompson, Ruiz, Ma, Kinch, Li, Grishin, Bruick: "An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis." in: Science (New York, N.Y.), Vol. 326, Issue 5953, pp. 722-6, 2009 (PubMed).

DeMeo, Mariani, Bhattacharya, Srisuma, Lange, Litonjua, Bueno, Pillai, Lomas, Sparrow, Shapiro, Criner, Kim, Chen, Choi, Reilly, Silverman: "Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene." in: American journal of human genetics, Vol. 85, Issue 4, pp. 493-502, 2009 (PubMed).