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WDR12 antibody (WD Repeat Domain 12) (AA 210-239)

Details for Product anti-WDR12 Antibody No. ABIN657000, Supplier: Log in to see
Antigen
  • 4933402C23Rik
  • fb24f09
  • WDR12
  • wu:fb24f09
  • Ytm1
  • YTM1
  • Ytm1p
  • zgc:55609
Epitope
AA 210-239, Center
28
16
16
3
2
1
1
1
Reactivity
Human
39
5
3
3
1
Host
Rabbit
40
Clonality (Clone)
Polyclonal ()
Conjugate
This WDR12 antibody is un-conjugated
4
4
4
4
4
4
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
37
29
14
2
1
Supplier
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Immunogen This WDR12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-239 AA from the Central region of human WDR12.
Clone RB33036
Isotype Ig
Specificity This WDR12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 209-239 amino acids from the Central region of human WDR12.
Predicted Reactivity Cow (Bovine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name WDR12 (WDR12 Antibody Abstract)
Background This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.
Synonyms: Ribosome biogenesis protein WDR12,WDR12,
Molecular Weight 47708 DA
Gene ID 55759
NCBI Accession NP_060726
UniProt Q9GZL7
Research Area Signaling, Protein Modifications, Transcription Factors, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment WDR12 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-WDR12 antibody (WD Repeat Domain 12) (AA 210-239) (ABIN657000) WDR12 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane)...
Immunohistochemistry (IHC) image for anti-WDR12 antibody (WD Repeat Domain 12) (AA 210-239) (ABIN657000) WDR12 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin ...
Background publications , Kathiresan, Voight, Purcell, Musunuru, Ardissino, Mannucci, Anand, Engert, Samani, Schunkert, Erdmann, Reilly, Rader, Morgan, Spertus, Stoll, Girelli, McKeown, Patterson, Siscovick, ODonnell, Elosua, Peltonen, Salomaa, Schwartz, Melander, Altshuler, Ard: "Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants." in: Nature genetics, Vol. 41, Issue 3, pp. 334-41, 2009

Grimm, Hölzel, Rohrmoser, Harasim, Malamoussi, Gruber-Eber, Kremmer, Eick: "Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex." in: Nucleic acids research, Vol. 34, Issue 10, pp. 3030-43, 2006

Hölzel, Rohrmoser, Schlee, Grimm, Harasim, Malamoussi, Gruber-Eber, Kremmer, Hiddemann, Bornkamm, Eick: "Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation." in: The Journal of cell biology, Vol. 170, Issue 3, pp. 367-78, 2005