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TLR7 antibody (Toll-Like Receptor 7) (AA 899-926)

Details for Product anti-TLR7 Antibody No. ABIN657635, Supplier: Log in to see
Antigen
  • RGD1563357
  • TLR7-like
  • TLR7A
Alternatives
anti-Human TLR7 antibody for Enzyme Immunoassay
Epitope
AA 899-926, C-Term
33
28
18
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12
7
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5
5
5
3
3
2
2
2
2
2
1
1
1
1
1
1
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1
Reactivity
Human
250
121
37
3
3
2
2
2
1
1
1
1
Host
Rabbit
192
82
2
1
Clonality (Clone)
Polyclonal ()
Conjugate
This TLR7 antibody is un-conjugated
16
13
12
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6
6
4
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4
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3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
199
99
89
54
43
39
35
17
12
6
1
1
1
Supplier
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Immunogen This TLR7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 899-926 AA from the C-terminal region of human TLR7.
Clone RB33653
Isotype Ig
Specificity This TLR7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 898-927 amino acids from the C-terminal region of human TLR7.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name TLR7 (TLR7 Antibody Abstract)
Background The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X.
Synonyms: Toll-like receptor 7,TLR7,
Molecular Weight 120922 DA
Gene ID 51284
NCBI Accession NP_057646
UniProt Q9NYK1
Research Area Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Chromatin, Signaling
Pathways TLR Signaling
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment TLR7 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-TLR7 antibody (Toll-Like Receptor 7) (AA 899-926) (ABIN657635) TLR7 Antibody (C-term) (ABIN657635) western blot analysis in HepG2 cell line lysates ...
Background publications Shen, Fu, Deng, Qian, Zhao, Kaufman, Wu, Yu, Tang, Chen, Yang, Wong, Kawasaki, Tsuchiya, Sumida, Kawaguchi, Howe, Mok, Bang, Liu, Chang, Takasaki, Hashimoto, Harley, Guthridge, Grossman, Cantor, Song, Bae, Chen, Hahn, Lau, Tsao: "Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 36, pp. 15838-43, 2010 (PubMed).