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Details for Product No. ABIN657648

NCK Adaptor Protein 1 (NCK1) (N-Term), (AA 63-92) antibody

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Antigen
Synonyms NCK, NCKalpha, nck-1, NCK1
Epitope
»Alternatives N-Term, AA 63-92
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 3 references available
Catalog no. ABIN657648
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This NCK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-92 AA from the N-terminal region of human NCK1.
Clone RB33697
Isotype Ig
Specificity This NCK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-92 amino acids from the N-terminal region of human NCK1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name NCK1
Background The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found.
Synonyms: Cytoplasmic protein NCK1,NCK1,NCK
Molecular Weight 42864 DA
Gene ID 4690
UniProt P16333, NP_006144.1, NP_001177725.1
Research Area Translation Factors, Signaling, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment NCK1 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Preisinger, Kolch: "The Bcr-Abl kinase regulates the actin cytoskeleton via a GADS/Slp-76/Nck1 adaptor protein pathway." in: Cellular signalling, Vol. 22, Issue 5, pp. 848-56, 2010 (PubMed).

Gehmlich, Hayess, Legler et al.: "Ponsin interacts with Nck adapter proteins: implications for a role in cytoskeletal remodelling during differentiation of skeletal muscle cells." in: European journal of cell biology, Vol. 89, Issue 5, pp. 351-64, 2010 (PubMed).

Barda-Saad, Shirasu, Pauker et al.: "Cooperative interactions at the SLP-76 complex are critical for actin polymerization." in: The EMBO journal, Vol. 29, Issue 14, pp. 2315-28, 2010 (PubMed).

Alternatives for antigen "NCK Adaptor Protein 1 (NCK1)", type "Antibodies"
Hosts (29), (16)
Reactivities (44), (12), (11), (3)
Applications (42), (17), (12), (8), (8), (7), (6), (3), (2), (2), (1), (1)
Epitopes (8), (3), (3), (2), (1), (1), (1), (1), (1), (1)
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