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Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 177-206), (Center) antibody

Details for Product No. ABIN657706, Supplier: Log in to see
Antigen
  • 5133400O11Rik
  • BB115266
  • D7Bwg0421e
  • Lair-1
  • mLair-1
  • CD305
  • LAIR-1
Epitope
AA 177-206, Center
30
16
9
6
6
5
4
4
3
2
1
1
1
1
1
1
1
Reactivity
Human
132
27
17
Host
Rabbit
77
53
18
4
3
1
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
22
13
9
5
4
3
3
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
97
69
56
24
13
11
7
3
2
1
1
1
1
1
Supplier
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Immunogen This LAIR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-206 AA from the Central region of human LAIR1.
Clone RB33925
Isotype Ig
Specificity This LAIR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-206 amino acids from the Central region of human LAIR1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name LAIR1 (LAIR1 Antibody Abstract)
Background The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.
Synonyms: Leukocyte-associated immunoglobulin-like receptor 1,LAIR1,CD305
Molecular Weight 31412 DA
Gene ID 3903
NCBI Accession NP_002278, NP_068352
UniProt Q6GTX8
Research Area Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications
Pathways
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment LAIR1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (AA 177-206), (Center) antibody (ABIN657706) LAIR1 Antibody (Center) (ABIN657706) western blot analysis in K562 cell line lysates ...
Background publications Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Brondijk, de Ruiter, Ballering et al.: "Crystal structure and collagen-binding site of immune inhibitory receptor LAIR-1: unexpected implications for collagen binding by platelet receptor GPVI." in: Blood, Vol. 115, Issue 7, pp. 1364-73, 2010 (PubMed).

Tang, Narayanan, Peruzzi et al.: "A single residue, arginine 65, is critical for the functional interaction of leukocyte-associated inhibitory receptor-1 with collagens." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 9, pp. 5446-52, 2009 (PubMed).