Topoisomerase (DNA) I (TOP1) (AA 2-31), (N-Term) antibody

Details for Product No. ABIN657818
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Antigen
Synonyms
CG6146, Dmel\\CG6146, TOP1, TopI, Topo I, TopoI, dTopoI, l(1)G0134, l(1)G0201, l(1)G0229, l(1)G0278, l(1)top1, top1, topo I, topoI, DNA topoisomerase 1 beta, DNA topoisomerase I alpha, MGO1, MGOUN 1,  ... show more
CG6146, Dmel\\CG6146, TOP1, TopI, Topo I, TopoI, dTopoI, l(1)G0134, l(1)G0201, l(1)G0229, l(1)G0278, l(1)top1, top1, topo I, topoI, DNA topoisomerase 1 beta, DNA topoisomerase I alpha, MGO1, MGOUN 1, MTE17.1, MTE17_1, TOP1BETA, TOPOISOMERASE 1, TOPI, AI467334, D130064I21Rik, Top-1, Ab2-086, topi show less
Epitope
AA 2-31, N-Term
(19), (11), (5), (3), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(47), (9), (9)
Host
Rabbit
(33), (12), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (2), (2), (2), (2)
Application
Immunofluorescence (IF), Western Blotting (WB)
(45), (24), (10), (6), (3), (3), (3), (2), (1), (1)
Pubmed 2 references available
Quantity 400 μL
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Immunogen This TOP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-31 AA from the N-terminal region of human TOP1.
Clone RB34034
Isotype Ig
Specificity This TOP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-31 amino acids from the N-terminal region of human TOP1.
Predicted Reactivity Hamster,Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name TOP1 (TOP1 Antibody Abstract)
Background This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.
Synonyms: DNA topoisomerase 1,TOP1,
Molecular Weight 90726 DA
Gene ID 7150
NCBI Accession NP_003277
UniProt P11387
Research Area Ubiquitin-related antibodies, Signaling, Phospho-specific antibodies, Protein Modifications, Cancer, Transcription Factors, Chromatin, Cell Structure
Application Notes WB = 1:1000, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment TOP1 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Topoisomerase (DNA) I (TOP1) (AA 2-31), (N-Term) antibody TOP1 Antibody (N-term) (ABIN657818) western blot analysis in NCI-H460 cell line lysat...
Background publications Kjeldsen, Tordrup, Hübner et al.: "Topoisomerase I deficiency results in chromosomal alterations in cervical cancer cells." in: Anticancer research, Vol. 30, Issue 9, pp. 3257-65, 2010 (PubMed).

Reinhold, Mergny, Liu et al.: "Exon array analyses across the NCI-60 reveal potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron." in: Cancer research, Vol. 70, Issue 6, pp. 2191-203, 2010 (PubMed).

Validation Images
Catalog No. ABIN657818
291.50 $
Plus shipping costs $45.00
Quantity
Price
400 μL
291.50 $

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