Retinoblastoma Binding Protein 8 antibody (C-Term)

Catalog No. ABIN657950

The Rabbit Polyclonal anti-Retinoblastoma Binding Protein 8 antibody has been validated for WB. It is suitable to detect Retinoblastoma Binding Protein 8 in samples from Human.

Quick Overview for Retinoblastoma Binding Protein 8 antibody (C-Term) (ABIN657950)

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Retinoblastoma Binding Protein 8 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB34059

Product Details anti-Retinoblastoma Binding Protein 8 Antibody

Binding Specificity: AA 763-792, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RBBP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 763-792 amino acids from the C-terminal region of human RBBP8.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: RBBP8 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

Target Details for Retinoblastoma Binding Protein 8

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Alternative Name: RBBP8

Background: The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.

Molecular Weight: 101942

Gene ID: 5932

NCBI Accession: NP_002885, NP_976036, NP_976037

UniProt: Q99708

Pathways: Cell Division Cycle, DNA Damage Repair