Beclin 1, Autophagy Related (BECN1) antibody

Details for Product No. ABIN658976
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Antigen
Synonyms ATG6, VPS30, beclin1, 4921513J16Rik, 5430417M23Rik, Atg6, zgc:73097, beclin-1, atg6, vps30, Beclin-1, becn1
Reactivity
Human
(165), (81), (57), (32), (30), (21), (18), (15), (12), (6), (2), (1)
Host
Mouse
(123), (53), (1), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(6), (6), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(162), (55), (50), (46), (37), (23), (18), (14), (10), (5), (5), (3), (1)
Pubmed 5 references available
Catalog no. ABIN658976
Quantity 0.1 mL
Price
291.50 $   Plus shipping costs $45.00
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Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This BECN1 Monoclonal antibody was raised using purified His-tagged recombinant full length human Autophagy BECN1.
Clone 117CT2-5-1-1
Isotype IgM
Specificity This BECN1 Monoclonal antibody was raised using purified His-tagged recombinant full length human Autophagy BECN1.
Purification Ascites
Alternative Name BECN1
Background Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 [PubMed 19270693]).
Synonyms: BECN1, ATG6, VPS30, beclin1, ATG6 autophagy related 6 homolog, beclin 1 (coiled-coil, moesin-like BCL2 interacting protein), beclin 1 (coiled-coil, moesin-like BCL2-interacting protein), beclin-1, coiled-coil myosin-like BCL2-interacting protein
Molecular Weight 51765 DA
Gene ID 8678
UniProt Q14457
Research Area Cell Signaling, Cell Structure, Autophagy
Application Notes WB = 1:100-400, IHC = 1:50-100, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Buffer Crude ascites with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Beclin 1, Autophagy Related (BECN1) antibody Western blot analysis of anti-BECN1 Monoclonal Antibody in Jurkat cell line lysates (35ug/lane). BECN1 (arrow) was detected using the Mab ascites (1:100 dilution).
anti-Beclin 1, Autophagy Related (BECN1) antibody (2) Formalin-fixed and paraffin-embedded human brain with BECN1 Monoclonal Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
anti-Beclin 1, Autophagy Related (BECN1) antibody (3) Immunofluorescence analysis of BECN1 Monoclonal Antibody with paraffin-embedded human brain tissue .0.05 mg/ml primary antibody was followed by PE-conjugated goat anti-mouse lgG (whole molecule). PE emits orange fluorescence.
Background publications Sun, Liu, Jin et al.: "Over-expression of the Beclin1 gene upregulates chemosensitivity to anti-cancer drugs by enhancing therapy-induced apoptosis in cervix squamous carcinoma CaSki cells." in: Cancer letters, Vol. 294, Issue 2, pp. 204-10, 2010 (PubMed).

Li, Chen, Wu et al.: "Genetic and epigenetic silencing of the beclin 1 gene in sporadic breast tumors." in: BMC cancer, Vol. 10, pp. 98, 2010 (PubMed).

Jaeger, Pickford, Sun et al.: "Regulation of amyloid precursor protein processing by the Beclin 1 complex." in: PLoS ONE, Vol. 5, Issue 6, pp. e11102, 2010 (PubMed).

Niu, Cheng, Ren et al.: "Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis." in: FEBS letters, Vol. 584, Issue 16, pp. 3519-24, 2010 (PubMed).

Metzger, Saukko, Van Che et al.: "Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7." in: Human genetics, Vol. 128, Issue 4, pp. 453-9, 2010 (PubMed).

Hosts (123), (53), (1), (1)
Reactivities (165), (81), (57), (32), (30), (21), (18), (15), (12), (6), (2), (1)
Applications (162), (55), (50), (46), (37), (23), (18), (14), (10), (5), (5), (3), (1)
Conjugates (6), (6), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (19), (17), (7), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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