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ITA6 antibody

Details for Product No. ABIN658988
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Antigen
Reactivity
Human
(2)
Host
Mouse
(1), (1)
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
(2), (1), (1), (1)
Pubmed 5 references available
Quantity 400 µL
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Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN658988
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen ITA6 recombinant protein is used to produce this monoclonal antibody.
Clone 129CT49-6-5
Isotype IgG1, Ig
Specificity ITA6 recombinant protein is used to produce this monoclonal antibody.
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Background The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms: Integrin alpha-6 light chain, Integrin alpha-6 heavy chain, CD_antigen=CD49f, CD49 antigen-like family member F, VLA-6, Integrin alpha-6,ITGA6
Molecular Weight 126633 DA
Gene ID 3655
UniProt P23229
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:100-16000, IHC = 1:10-50, IF = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.42 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-ITA6 antibody Western blot analysis of anti-ITA6 in HepG2 cell line lysates (35ug/lane). ITA6 (arrow) was detected using the purified Mab.(8ug/ml)
anti-ITA6 antibody (2) ITA6 Monoclonal Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human skin carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ITA6 Monoclonal Antibody for immunohistochemistry. Clinical relevance has not been evaluated.
anti-ITA6 antibody (3) Confocal immunofluorescent analysis of ITA6 Antibody with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-mouse lgG (green). DAPI was used to stain the cell nuclear (blue).
anti-ITA6 antibody (4) ITA6 Monoclonal Antibody flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).PE-conjugated goat-anti-mouse secondary antibodies were used for the analysis.
Background publications Abban, Meneses: "Usage of heparan sulfate, integrins, and FAK in HPV16 infection." in: Virology, Vol. 403, Issue 1, pp. 1-16, 2010 (PubMed).

Wang, Fu, Xie et al.: "Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population." in: Journal of human genetics, Vol. 55, Issue 8, pp. 490-4, 2010 (PubMed).

Bouvard, Gafsou, Dizier et al.: "alpha6-integrin subunit plays a major role in the proangiogenic properties of endothelial progenitor cells." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 30, Issue 8, pp. 1569-75, 2010 (PubMed).

Kim, Cheng, Hsu et al.: "Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation." in: The Prostate, Vol. 70, Issue 16, pp. 1729-38, 2010 (PubMed).

Johnatty, Beesley, Chen et al.: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN658988
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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