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EZH2 antibody (Enhancer of Zeste Homolog 2 (Drosophila))

Details for Product anti-EZH2 Antibody No. ABIN659002, Supplier: Log in to see
Antigen
  • EZH2
  • enx-1
  • enx1
  • ezh1
  • kmt6
  • xez
  • ezh2
  • olezh2
  • ENX-1
  • ENX1
  • EZH1
  • EZH2b
  • KMT6
  • KMT6A
  • WVS
  • WVS2
  • Enx-1
  • Enx1h
  • mKIAA4065
  • eya2
  • im:7149338
  • zgc:136376
  • zgc:152758
  • enhancer of zeste homolog 2 (Drosophila)
  • enhancer of zeste homolog 2
  • EZH2
  • ezh2
  • ezh2-a
  • Ezh2
Alternatives
anti-Human EZH2 antibody for ELISA
Reactivity
Human
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1
Host
Mouse
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1
Clonality (Clone)
Monoclonal ()
Conjugate
This EZH2 antibody is un-conjugated
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1
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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45
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16
11
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3
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2
1
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Options
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Immunogen This EZH2 antibody is generated from mouse immunized with EZH2 recombinant protein.
Clone 144CT2-1-1-5
Isotype IgG1, Ig kappa
Specificity This EZH2 antibody is generated from mouse immunized with EZH2 recombinant protein.
Predicted Reactivity Monkey
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name EZH2 (EZH2 Antibody Abstract)
Background This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Two transcript variants encoding distinct isoforms have been identified for this gene.
Synonyms: Lysine N-methyltransferase 6, ENX-1, Enhancer of zeste homolog 2, Histone-lysine N-methyltransferase EZH2,KMT6, EZH2
Molecular Weight 85363 Da
Gene ID 2146
UniProt Q15910
Research Area Translation Factors
Pathways Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation
Application Notes IF = 1:10-50, WB = 1:100-500, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Immunofluorescence (IF) image for anti-EZH2 antibody (Enhancer of Zeste Homolog 2 (Drosophila)) (ABIN659002) Fluorescent image of U251 cell stained with EZH2 Antibody.U251 cells were fixed with ...
Western Blotting (WB) image for anti-EZH2 antibody (Enhancer of Zeste Homolog 2 (Drosophila)) (ABIN659002) Western blot analysis of EZH2 antibody in T47D cell line lysates (35ug/lane).EZH2 (a...
Immunohistochemistry (IHC) image for anti-EZH2 antibody (Enhancer of Zeste Homolog 2 (Drosophila)) (ABIN659002) EZH2 Monoclonal Antibody immunohistochemistry analysis in formalin fixed and paraffi...
Product cited in: Zhang, Ji, Liu, Lei, Li, Ji, Yuan, Jiao: "Ezh2 regulates adult hippocampal neurogenesis and memory." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 15, pp. 5184-99, 2014 (PubMed).

Background publications Tsai, Manor, Wan, Mosammaparast, Wang, Lan, Shi, Segal, Chang: "Long noncoding RNA as modular scaffold of histone modification complexes." in: Science (New York, N.Y.), Vol. 329, Issue 5992, pp. 689-93, 2010 (PubMed).

Toll, Dasgupta, Potoczek, Yeo, Kleer, Brody, Witkiewicz: "Implications of enhancer of zeste homologue 2 expression in pancreatic ductal adenocarcinoma." in: Human pathology, Vol. 41, Issue 9, pp. 1205-9, 2010 (PubMed).

Kikuchi, Kinoshita, Shimizu, Kikuchi, Konishi, Oizumi, Kaga, Matsuno, Nishimura, Dosaka-Akita: "Distinctive expression of the polycomb group proteins Bmi1 polycomb ring finger oncogene and enhancer of zeste homolog 2 in nonsmall cell lung cancers and their clinical and clinicopathologic significance." in: Cancer, Vol. 116, Issue 12, pp. 3015-24, 2010 (PubMed).

Wang, Ye, Yuan, Liu, Zhang, Wang: "EZH2 and STAT6 expression profiles are correlated with colorectal cancer stage and prognosis." in: World journal of gastroenterology : WJG, Vol. 16, Issue 19, pp. 2421-7, 2010 (PubMed).

Kunderfranco, Mello-Grand, Cangemi, Pellini, Mensah, Albertini, Malek, Chiorino, Catapano, Carbone: "ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer." in: PLoS ONE, Vol. 5, Issue 5, pp. e10547, 2010 (PubMed).