Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3 (MAP4K3) antibody

Antigen: Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3 (MAP4K3)

Synonyms: GLK, MAPKKKK3, RAB8IPL1

Clonality: Monoclonal

Host: Mouse

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN659123

Additional Information

Alternative name: MAP4K3

Gene ID: 8491

UniProt: NP_003609.2, Q8IVH8

Immunogen: This MAP4K3 monoclonal antibody is generated from mouse immunized with MAP4K3 recombinant protein.

Isotype: IgM, kappa chain

Description: Other names: Mitogen-activated protein kinase kinase kinase kinase 3,MAP4K3,RAB8IPL1

Characteristics: Mouse Monoclonal Antibody (Mab)

Specificity: This MAP4K3 monoclonal antibody is generated from mouse immunized with MAP4K3 recombinant protein.

Molecular Weight: 101316 DA

Comments:

Background: This gene encodes a member of the Ste20 family of serine/threonine protein kinases. The protein belongs to the subfamily that consists of members, such as germinal center kinase (GCK), that are characterized by an N-terminal catalytic domain and C-terminal regulatory domain. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase kinase 1 (MEKK1). This gene previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3).

Application Details

Application Notes: The suggested dilution is: ELISA~~1:1000 Western blotting~~1:60~500

Concentration: 0.25 mg/ml

Buffer: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.

Storage: MAP4K3 Antibody can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.

Research Area: Phospho-specific antibodies, Cell Signaling, Protein Modifications, Signaling, Chromatin, Cell Structure

Restrictions: For Research Use only

Publications

Product: Yan, Mieulet, Burgess et al.: "PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR." in: Molecular cell, Vol. 37, Issue 5, pp. 633-42, 2010 (PubMed).