MAP4K3 antibody (C-Term)

Catalog No. ABIN392541

The Rabbit Polyclonal anti-MAP4K3 antibody (Clone RB1264) (ABIN392541) specifically detects MAP4K3 in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for MAP4K3 antibody (C-Term) (ABIN392541)

Target: MAP4K3 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3 (MAP4K3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP4K3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB1264

Product Details anti-MAP4K3 Antibody

Binding Specificity: AA 423-453, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This GLK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 423-453 amino acids from the C-terminal region of human GLK.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for MAP4K3

Target: MAP4K3 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3 (MAP4K3))

Alternative Name: GLK

Background: GLK is a member of the Ste20 family of serine/threonine protein kinases. The protein belongs to the subfamily that consists of members, such as germinal center kinase (GCK), that are characterized by an N-terminal catalytic domain and C-terminal regulatory domain. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase kinase 1 (MEKK1). This gene previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3).

Molecular Weight: 101316

Gene ID: 8491

NCBI Accession: NP_001257354, NP_003609

UniProt: Q8IVH8

Pathways: MAPK Signaling