AATF antibody (AA 451-560)

Catalog No. ABIN673689

The Rabbit Polyclonal anti-AATF antibody (ABIN673689) specifically detects AATF in ELISA, IHC (p), IF (cc), IF (p) and IHC (fro). The antibody is reactive with Human samples.

Quick Overview for AATF antibody (AA 451-560) (ABIN673689)

Target: AATF (Apoptosis Antagonizing Transcription Factor (AATF))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AATF antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-AATF Antibody

Binding Specificity: AA 451-560

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Cow,Pig,Horse,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human AATF

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for AATF

Target: AATF (Apoptosis Antagonizing Transcription Factor (AATF))

Alternative Name: AATF

Background:

Synonyms: DED, BFR2, CHE1, CHE-1, Protein AATF, Apoptosis-antagonizing transcription factor, Rb-binding protein Che-1, AATF, HSPC277

Background: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.

Gene ID: 26574

UniProt: Q9NY61

Pathways: Neurotrophin Signaling Pathway, SARS-CoV-2 Protein Interactome