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CHMP1A antibody (AA 51-150)

CHMP1A Reactivity: Human, Mouse IF (cc), IF (p), IHC (fro), IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN705236
  • Target See all CHMP1A Antibodies
    CHMP1A (Charged Multivesicular Body Protein 1A (CHMP1A))
    Binding Specificity
    • 8
    • 8
    • 7
    • 6
    • 1
    AA 51-150
    Reactivity
    • 35
    • 12
    • 2
    Human, Mouse
    Host
    • 31
    • 4
    Rabbit
    Clonality
    • 35
    Polyclonal
    Conjugate
    • 14
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CHMP1A antibody is un-conjugated
    Application
    • 24
    • 19
    • 5
    • 4
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human, Mouse
    Predicted Reactivity
    Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human CHMP1A
    Isotype
    IgG
    Top Product
    Discover our top product CHMP1A Primary Antibody
  • Application Notes
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    CHMP1A (Charged Multivesicular Body Protein 1A (CHMP1A))
    Alternative Name
    CHMP1A (CHMP1A Products)
    Synonyms
    CHMP1 antibody, PCH8 antibody, PCOLN3 antibody, PRSM1 antibody, VPS46-1 antibody, VPS46A antibody, 2900018H07Rik antibody, Pcoln3 antibody, charged multivesicular body protein 1A antibody, CHMP1A antibody, Chmp1a antibody
    Background

    Synonyms: PCH8, CHMP1, PRSM1, PCOLN3, VPS46A, VPS46-1, Charged multivesicular body protein 1a, Chromatin-modifying protein 1a, CHMP1a, Vacuolar protein sorting-associated protein 46-1, hVps46-1, KIAA0047

    Background: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.

    Gene ID
    5119
    UniProt
    Q9HD42
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