This antibody detects LRRFIP2 at C-term. Three isoforms of LRRFIP2 are known to exist, this antibody will recognize all three. LRRFIP2 antibody is predicted to not cross-react with other LRRFIP family members.
Cross-Reactivity (Details)
Species reactivity (tested):Human, mouse, rat
Purification
Affinity chromatography purified via peptide column
Immunogen
17 amino acid peptide near the carboxy terminus of human LRRFIP2
HUFI-2 antibody, 5133400F20Rik antibody, AI850587 antibody, wu:fj34c02 antibody, zgc:113956 antibody, zgc:63771 antibody, LRR binding FLII interacting protein 2 antibody, leucine rich repeat (in FLII) interacting protein 2 antibody, leucine rich repeat (in FLII) interacting protein 2 L homeolog antibody, LRRFIP2 antibody, Lrrfip2 antibody, lrrfip2 antibody, lrrfip2.L antibody
Background
The leucine-rich repeat FLI-I-interacting protein 2 (LRRFIP2), like the related protein LRRFIP1, was identified in a yeast two-hybrid system through binding to the LRR domain of human FLI. It can activate the Wnt signaling pathway in cultured cells and is thought to be a component of the Wnt signaling pathway that modulates Wnt signaling through interactions with Disheveled to increase the cellular levels and transcription activity of b-catenin. LRRFIP2 has recently been characterized as a positive regulator of the TLR4 signaling pathway for activating NF-kB during the early host response to LPS stimulation through binding to the TLR adaptor protein MyD88, and that this interaction with MyD88 is governed by phosphorylation of specific residues in LRRFIP2.Synonyms: LRR FLII-interacting protein 2, Leucine-rich repeat flightless-interacting protein 2