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ATPase, Ca++ Transporting, Type 2C, Member 2 (ATP2C2) (N-Term) antibody

Details for Product No. ABIN783440
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Antigen
Synonyms 1810010G06Rik, Spca2, mKIAA0703, SPCA2, KIAA0703, MGC146612
Epitope
N-Term
(7), (1)
Reactivity
Human, Mouse (Murine)
(12), (6)
Host
Rabbit
(10), (1)
Clonality
Polyclonal
Application
ELISA, Western Blotting (WB)
(11), (8), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN783440
401.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen 19 amino acid peptide near the amino terminus of human ATP2C2
Specificity This antibody detects ATP2C2 at N-term. At least three isoforms of ATP2C2 are known to exist. ATP2C2 antibody will not cross-react with ATP2C1. Species Reactivity: Tested: Human, mouse
Purification Affinity chromatography purified via peptide column
Alternative Name ATP2C2
Background ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles. Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation. Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.
Alternate names: ATP2C2, ATPase 2C2, Calcium-transporting ATPase type 2C member, EC=3.6.3.8, KIAA0703, SPCA2, Secretory pathway Ca(2+)-ATPase 2
Gene ID 9914
NCBI Accession NP_055676
UniProt O75185
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Hu, Bonifas, Beech et al.: "Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease." in: Nature genetics, Vol. 24, Issue 1, pp. 61-5, 2000 (PubMed).

Xiang, Mohamalawari, Rao: "A novel isoform of the secretory pathway Ca2+,Mn(2+)-ATPase, hSPCA2, has unusual properties and is expressed in the brain." in: The Journal of biological chemistry, Vol. 280, Issue 12, pp. 11608-14, 2005 (PubMed).

Dode, Andersen, Vanoevelen et al.: "Dissection of the functional differences between human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and 2 isoenzymes by steady-state and transient kinetic analyses." in: The Journal of biological chemistry, Vol. 281, Issue 6, pp. 3182-9, 2006 (PubMed).

Hosts (10), (1)
Reactivities (12), (6)
Applications (11), (8), (1), (1)
Epitopes (7), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN783440
401.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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