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ATPase, Ca++ Transporting, Type 2C, Member 2 (ATP2C2) (N-Term) antibody

Details for Product No. ABIN783440, Supplier: Log in to see
Antigen
  • KIAA0703
  • MGC146612
  • SPCA2
  • 1810010G06Rik
  • Spca2
  • mKIAA0703
Epitope
N-Term
6
1
Reactivity
Human, Mouse (Murine)
9
5
Host
Rabbit
8
Clonality
Polyclonal
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
8
7
2
1
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Immunogen 19 amino acid peptide near the amino terminus of human ATP2C2
Specificity This antibody detects ATP2C2 at N-term. At least three isoforms of ATP2C2 are known to exist. ATP2C2 antibody will not cross-react with ATP2C1.
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse
Purification Affinity chromatography purified via peptide column
Alternative Name ATP2C2 (ATP2C2 Antibody Abstract)
Background ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles. Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation. Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.Synonyms: ATP2C2, ATPase 2C2, Calcium-transporting ATPase type 2C member, EC=3.6.3.8, KIAA0703, SPCA2, Secretory pathway Ca(2+)-ATPase 2
Gene ID 9914
NCBI Accession NP_055676
UniProt O75185
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-ATPase, Ca++ Transporting, Type 2C, Member 2 (ATP2C2) (N-Term) antibody (ABIN783440) Western blot analysis of ATP2C2 in 3T3 cell lysate with ATP2C2 antibody at 1 μg/ml in...
Background publications Dode, Andersen, Vanoevelen et al.: "Dissection of the functional differences between human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and 2 isoenzymes by steady-state and transient kinetic analyses." in: The Journal of biological chemistry, Vol. 281, Issue 6, pp. 3182-9, 2006 (PubMed).

Xiang, Mohamalawari, Rao: "A novel isoform of the secretory pathway Ca2+,Mn(2+)-ATPase, hSPCA2, has unusual properties and is expressed in the brain." in: The Journal of biological chemistry, Vol. 280, Issue 12, pp. 11608-14, 2005 (PubMed).

Hu, Bonifas, Beech et al.: "Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease." in: Nature genetics, Vol. 24, Issue 1, pp. 61-5, 2000 (PubMed).