STEAP4 antibody (Center)

Catalog No. ABIN783554

Product Details anti-STEAP4 Antibody

Target: STEAP4 (STEAP Family Member 4 (STEAP4))

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STEAP4 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects STEAP4 at Center.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 14 amino acid peptide from near the center of human STEAP4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for STEAP4

Target: STEAP4 (STEAP Family Member 4 (STEAP4))

Alternative Name: STEAP4 (STEAP4 Products)

Synonyms: STAMP2 antibody, TIARP antibody, TNFAIP9 antibody, MGC68826 antibody, STEAP4 antibody, MGC108044 antibody, steap4 antibody, 1110021O17Rik antibody, AI481214 antibody, Tiarp antibody, Tnfaip9 antibody, si:dkey-53p21.1 antibody, zgc:112143 antibody, STEAP4 metalloreductase antibody, STEAP4 metalloreductase L homeolog antibody, metalloreductase STEAP4 antibody, STEAP family member 4 antibody, STEAP4 antibody, steap4.L antibody, Steap4 antibody, steap4 antibody, LOC100136336 antibody, LOC100353852 antibody

Background: The six-transmembrane epithelial antigen of prostate 4 (STEAP4) is a member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. Similar to two other members of the STEAP family (STEAP 2 and STEAP3), STEAP4 promotes both iron and copper reduction. STEAP4 is highly expressed in placenta, lung, heart and prostate tissues, and overexpressed in prostate cancer cells compared to normal prostate cells. Overexpression of STEAP4 in prostate cells significantly increases cell growth and colony formation, suggesting STEAP4 may have a role in cell proliferation and prostate cancer progression. At least two isoforms are known to exist for this protein. This STEAP4 antibody does not cross-react with other STEAP proteins.Synonyms: Metalloreductase STEAP4, STAMP2, STEAP-4, Six-transmembrane epithelial antigen of prostate 4, SixTransMembrane protein of prostate 2, TNFAIP9, Tumor necrosis factor, alpha-induced protein 9

Gene ID: 79689

NCBI Accession: NP_078912

UniProt: Q687X5

Pathways: Transition Metal Ion Homeostasis