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NLR Family, Pyrin Domain Containing 6 (NLRP6) (N-Term) antibody

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Synonyms NLRP6, NALP6, AVR, CLR11.4, NAVR, NAVR/AVR, PAN3, PYPAF5, AI504961, Avr, Nalp6, Navr, Navr/Avr, Pypaf5
(22), (15), (15), (13), (11), (4), (3), (3), (2)
(41), (30), (8)
(57), (4)
(5), (5), (4), (4), (4), (4), (2)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(50), (41), (4), (3), (3), (3), (1), (1)
Pubmed 2 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen 16 amino acid peptide near the amino terminus of human NALP6
Specificity This antibody detects NLRP6 at N-term.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Affinity chromatography purified via peptide column
Alternative Name NLRP6 (NLRP6 Antibody Abstract)
Background NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP6, also known as PYPAF5, is highly expressed in granulocytes and T cells and co-localizes with the PYRIN-CARD protein ASC. Co-expression of NALP6 with ASC results in a synergistic activation of NF-kB and activated caspase-1-dependent cytokine processing, suggesting that NALP6 functions in immune cells to coordinate the transduction of pro-inflammatory signals.Synonyms: LRR and PYD domains-containing protein 6, NACHT, NALP6, PYPAF5
Gene ID 171389
NCBI Accession NP_612202
UniProt P59044
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-NLR Family, Pyrin Domain Containing 6 (NLRP6) (N-Term) antibody (ABIN783709) Western blot analysis of NALP5 in mouse brain tissue lysate with NALP5 antibody at 1 ...
Background publications Tian, Pascal, Monget: "Evolution and functional divergence of NLRP genes in mammalian reproductive systems." in: BMC evolutionary biology, Vol. 9, pp. 202, 2009 (PubMed).

Tschopp, Martinon, Burns: "NALPs: a novel protein family involved in inflammation." in: Nature reviews. Molecular cell biology, Vol. 4, Issue 2, pp. 95-104, 2003 (PubMed).

Catalog No. ABIN783709
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