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NLR Family, Pyrin Domain Containing 6 (NLRP6) (N-Term) antibody

Details for Product No. ABIN783709, Supplier: Login to see
Antigen
  • NLRP6
  • NALP6
  • AVR
  • CLR11.4
  • NAVR
  • NAVR/AVR
  • PAN3
  • PYPAF5
  • AI504961
  • Avr
  • Nalp6
  • Navr
  • Navr/Avr
  • Pypaf5
Epitope
N-Term
22
15
15
13
11
4
3
3
2
Reactivity
Human
41
30
8
Host
Rabbit
57
4
Clonality
Polyclonal
Conjugate
Un-conjugated
5
5
4
4
4
4
2
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
50
41
4
3
3
3
1
1
Supplier
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Immunogen 16 amino acid peptide near the amino terminus of human NALP6
Specificity This antibody detects NLRP6 at N-term.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Affinity chromatography purified via peptide column
Alternative Name NLRP6 (NLRP6 Antibody Abstract)
Background NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP6, also known as PYPAF5, is highly expressed in granulocytes and T cells and co-localizes with the PYRIN-CARD protein ASC. Co-expression of NALP6 with ASC results in a synergistic activation of NF-kB and activated caspase-1-dependent cytokine processing, suggesting that NALP6 functions in immune cells to coordinate the transduction of pro-inflammatory signals.Synonyms: LRR and PYD domains-containing protein 6, NACHT, NALP6, PYPAF5
Gene ID 171389
NCBI Accession NP_612202
UniProt P59044
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-NLR Family, Pyrin Domain Containing 6 (NLRP6) (N-Term) antibody (ABIN783709) Western blot analysis of NALP5 in mouse brain tissue lysate with NALP5 antibody at 1 ...
Background publications Tian, Pascal, Monget: "Evolution and functional divergence of NLRP genes in mammalian reproductive systems." in: BMC evolutionary biology, Vol. 9, pp. 202, 2009 (PubMed).

Tschopp, Martinon, Burns: "NALPs: a novel protein family involved in inflammation." in: Nature reviews. Molecular cell biology, Vol. 4, Issue 2, pp. 95-104, 2003 (PubMed).