NLRP6 antibody (N-Term)

Catalog No. ABIN657452

Product Details anti-NLRP6 Antibody

Target: NLRP6 (NLR Family, Pyrin Domain Containing 6 (NLRP6))

Binding Specificity: AA 168-197, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP6 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NLRP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the N-terminal region of human NLRP6.

Clone: RB33587

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000. WB: 1:4000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: NLRP6 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

Target Details for NLRP6

Target: NLRP6 (NLR Family, Pyrin Domain Containing 6 (NLRP6))

Alternative Name: NLRP6 (NLRP6 Products)

Synonyms: NLRP6 antibody, NALP6 antibody, AVR antibody, CLR11.4 antibody, NAVR antibody, NAVR/AVR antibody, PAN3 antibody, PYPAF5 antibody, AI504961 antibody, Avr antibody, Nalp6 antibody, Navr antibody, Navr/Avr antibody, Pypaf5 antibody, NLR family pyrin domain containing 6 antibody, NLR family, pyrin domain containing 6 antibody, NLRP6 antibody, Nlrp6 antibody

Background: NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP6, have an N-terminal pyrin (MEFV, MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1, MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).

Molecular Weight: 98768

Gene ID: 171389

NCBI Accession: NP_001263629, NP_612202

UniProt: P59044

Pathways: Inflammasome