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NLR Family, Pyrin Domain Containing 8 (NLRP8) (N-Term) antibody

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Antigen
Synonyms CLR19.2, NALP8, NOD16, PAN4
Epitope
N-Term
(9), (1), (1)
Reactivity
Human
(11)
Host
Rabbit
(10), (1)
Clonality
Polyclonal
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(11), (10), (3), (2)
Pubmed 1 reference available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen 16 amino acid peptide near the amino terminus of Human NALP8
Specificity This antibody detects NALP8 at N-term. This antibody is predicted to not cross-react with other NALP family members.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity Chromatography purified via peptide column
Alternative Name NALP8
Background NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP8 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It maps to chromosome 19q13.42 and is thought to be expressed in testis and ovary, suggesting that NALP8 may be involved in reproduction. Surprisingly, NALP8 seems to be universal in mammals except for rodents, suggesting that the gene may have been lost during evolution.Synonyms: LRR and PYD domains-containing protein 8, NACHT, NLRP8, NOD16, PAN4, PYRIN and NACHT-containing protein 4
Gene ID 126205
NCBI Accession NP_789781
UniProt Q86W28
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-NLR Family, Pyrin Domain Containing 8 (NLRP8) (N-Term) antibody (ABIN783713) Western blot analysis of NALP8 in human colon tissue lysate with NALP8 antibody at 1 ...
Background publications Tschopp, Martinon, Burns: "NALPs: a novel protein family involved in inflammation." in: Nature reviews. Molecular cell biology, Vol. 4, Issue 2, pp. 95-104, 2003 (PubMed).

Catalog No. ABIN783713
$401.50
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