NALP8 antibody (N-Term)

Catalog No. ABIN783713

Product Details anti-NALP8 Antibody

Target: NALP8 (NLRP8) (NLR Family, Pyrin Domain Containing 8 (NLRP8))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NALP8 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects NALP8 at N-term. This antibody is predicted to not cross-react with other NALP family members.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity Chromatography purified via peptide column

Immunogen: 16 amino acid peptide near the amino terminus of Human NALP8

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for NALP8

Target: NALP8 (NLRP8) (NLR Family, Pyrin Domain Containing 8 (NLRP8))

Alternative Name: NALP8 (NLRP8 Products)

Synonyms: CLR19.2 antibody, NALP8 antibody, NOD16 antibody, PAN4 antibody, NLR family pyrin domain containing 8 antibody, NLRP8 antibody

Background: NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP8 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It maps to chromosome 19q13.42 and is thought to be expressed in testis and ovary, suggesting that NALP8 may be involved in reproduction. Surprisingly, NALP8 seems to be universal in mammals except for rodents, suggesting that the gene may have been lost during evolution.Synonyms: LRR and PYD domains-containing protein 8, NACHT, NLRP8, NOD16, PAN4, PYRIN and NACHT-containing protein 4

Gene ID: 126205

NCBI Accession: NP_789781

UniProt: Q86W28

Pathways: Inflammasome