NLRP11 antibody (C-Term)

Catalog No. ABIN783717

The Rabbit Polyclonal anti-NLRP11 antibody (ABIN783717) specifically detects NLRP11 in WB, IHC (p) and EIA. The antibody is reactive with Human samples.

Quick Overview for NLRP11 antibody (C-Term) (ABIN783717)

Target: NLRP11 (NLR Family, Pyrin Domain Containing 11 (NLRP11))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP11 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-NLRP11 Antibody

Binding Specificity: C-Term

Specificity: This antibody will recognize all three isoforms of NALP2 and is predicted to not cross-react with other NALP family members.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Affinity Chromatography purified via peptide column

Immunogen: 15 amino acid peptide near the carboxy terminus of Human NALP11

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for NLRP11

Target: NLRP11 (NLR Family, Pyrin Domain Containing 11 (NLRP11))

Alternative Name: NALP11

Background: NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP11 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. While little is known about the function of NALP11, it has been suggested that it has been associated with Crohn's disease.Synonyms: LRR and PYD domains-containing protein 11, NACHT, NLRP11, NOD17, Nucleotide-binding oligomerization domain protein 17, PYPAF6, PYRIN-containing APAF1-like protein 6

Gene ID: 204801

NCBI Accession: NP_659444

UniProt: P59045

Pathways: Inflammasome