NLR Family, Pyrin Domain Containing 11 (NLRP11) (C-Term) antibody

Details for Product No. ABIN783717
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Antigen
Synonyms CLR19.6, NALP11, NOD17, PAN10, PYPAF6, PYPAF7
Epitope
C-Term
(7), (2), (2), (1)
Reactivity
Human
(14)
Host
Rabbit
(12), (2)
Clonality
Polyclonal
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(11), (10), (6), (4), (2), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN783717
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Immunogen 15 amino acid peptide near the carboxy terminus of Human NALP11
Specificity This antibody will recognize all three isoforms of NALP2 and is predicted to not cross-react with other NALP family members. Species Reactivity: Tested: Human
Purification Affinity Chromatography purified via peptide column
Alternative Name NALP11
Background NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP11 has a C-terminal leucine-rich repeat (LRR) region, an N- terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. While little is known about the function of NALP11, it has been suggested that it has been associated with Crohn's disease.
Alternate names: LRR and PYD domains-containing protein 11, NACHT, NLRP11, NOD17, Nucleotide-binding oligomerization domain protein 17, PYPAF6, PYRIN-containing APAF1-like protein 6
Gene ID 204801
NCBI Accession NP_659444
UniProt P59045
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Tschopp, Martinon, Burns: "NALPs: a novel protein family involved in inflammation." in: Nature reviews. Molecular cell biology, Vol. 4, Issue 2, pp. 95-104, 2003 (PubMed).

Tian, Pascal, Monget: "Evolution and functional divergence of NLRP genes in mammalian reproductive systems." in: BMC evolutionary biology, Vol. 9, pp. 202, 2009 (PubMed).

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