LZT-Hs2 antibody, 2900042E17Rik antibody, 5430433I10 antibody, mKIAA1265 antibody, Slc39a10 antibody, Zip10 antibody, zgc:63552 antibody, DKFZp459C165 antibody, solute carrier family 39 member 10 antibody, solute carrier family 39 (zinc transporter), member 10 antibody, solute carrier family 39 (zinc transporter), member 4-like antibody, SLC39A10 antibody, Slc39a10 antibody, Slc39a4l antibody, slc39a10 antibody
Background
ZIP10, also known as Slc39A10, is a widely expressed zinc transporter with nine transmembrane domains. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP10 mRNA was found to be significantly decreased in the intestines and kidneys of hypothyroid rats and increased in those of hyperthyroid rats, indicating that ZIP10 is positively regulated by thyroid hormones. ZIP10 mRNA was also found to be upregulated in invasive and metastatic breast cancer and cell lines, suggesting that ZIP10 could serve as a possible marker for the metastatic phenotype and possibly a target for novel treatment strategies. At least three isoforms of ZIP10 are known to exist. This antibody will not cross-react with the zinc transporter ZIP11.Synonyms: KIAA1265, Solute carrier family 39 member 10, ZIP-10, ZIP10, Zrt-and Irt-like protein 10