IGF1R antibody (pTyr1165, pTyr1166) (Cy5.5)

Catalog No. ABIN802238

The Rabbit Polyclonal anti-IGF1R antibody is suitable to detect IGF1R in samples from Mouse and Rat. It has been validated for FACS.

Quick Overview for IGF1R antibody (pTyr1165, pTyr1166) (Cy5.5) (ABIN802238)

Target: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IGF1R antibody is conjugated to Cy5.5

Application: Flow Cytometry (FACS)

Product Details anti-IGF1R Antibody (Cy5.5)

Binding Specificity: pTyr1165, pTyr1166

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Pig,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human IGF1R around the phosphorylation site of Tyr1165+Tyr1166

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for IGF1R

Target: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Alternative Name: IGF1R +

Background:

Synonyms: IGF-1R Tyr1165/Tyr1166, IGF1R phospho Y1165+Y1166, IGF1R phospho Tyr1165+Tyr1166, p-IGF1R Tyr1165+Tyr1166, CD221, CD221 antigen, IGF 1 receptor, IGF 1R, IGF I receptor, IGF1R, IGFIR, IGFIRC, Insulin like growth factor 1 receptor, Insulin like growth factor 1 receptor precursor, JTK13, MGC142170, MGC142172, IGF1 Receptor, IGF1R_HUMAN.

Background: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq, Jul 2008].

Gene ID: 3480

UniProt: P08069

Pathways: RTK Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy