RASSF1 antibody (AA 1-341)

Catalog No. ABIN2730557

The Mouse Monoclonal anti-RASSF1 antibody (Clone 9F5) (ABIN2730557) specifically detects RASSF1 in WB, IF and FACS. The antibody is reactive with Human samples.

Quick Overview for RASSF1 antibody (AA 1-341) (ABIN2730557)

Target: RASSF1 (Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RASSF1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: 9F5

Product Details anti-RASSF1 Antibody

Binding Specificity: AA 1-341

Characteristics: Homo sapiens Ras association (RalGDS/AF-6) domain family member 1 (RASSF1), transcript variant A

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Human recombinant protein fragment corresponding to amino acids 1-341 of human RASSF1(NP_009113) produced in HEK293T cell.

Isotype: IgG1

Application Details

Application Notes: WB 1:2000, IF 1:100, FLOW 1:100,

Comment:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for RASSF1

Target: RASSF1 (Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1))

Alternative Name: RASSF1

Background: This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Molecular Weight: 38.6 kDa

Gene ID: 11186

NCBI Accession: NM_007182

HGNC: 11186