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RASSF1 antibody (AA 145-260)

RASSF1 Reactivity: Human, Mouse, Rat ELISA, IF (cc), IF (p), IHC (fro), IHC (p) Host: Rabbit Polyclonal unconjugated
Pubmed (2 references)
Catalog No. ABIN673764
$384.62
Plus shipping costs $45.00
100 μL
Shipping to: United States
Delivery in 4 to 6 Business Days
  • Target See all RASSF1 Antibodies
    RASSF1 (Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1))
    Binding Specificity
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 145-260
    Reactivity
    • 17
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 13
    • 4
    Rabbit
    Clonality
    • 13
    • 4
    Polyclonal
    Conjugate
    • 13
    • 2
    • 1
    • 1
    This RASSF1 antibody is un-conjugated
    Application
    • 9
    • 9
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Predicted Reactivity
    Cow,Sheep,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human RASSF1
    Isotype
    IgG
  • Application Notes
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Klacz, Wierzbicki, Wronska, Rybarczyk, Stanislawowski, Slebioda, Olejniczak, Matuszewski, Kmiec: "Decreased expression of RASSF1A tumor suppressor gene is associated with worse prognosis in clear cell renal cell carcinoma." in: International journal of oncology, Vol. 48, Issue 1, pp. 55-66, (2015) (PubMed).

    Liu, Ao, Zhou, Cui, Zhou, Yuan, Xiang, Cao, Liu: "CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine." in: Biochemical and biophysical research communications, Vol. 402, Issue 3, pp. 507-14, (2010) (PubMed).

  • Target
    RASSF1 (Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1))
    Alternative Name
    RASSF1 (RASSF1 Products)
    Synonyms
    RASSF1 antibody, zgc:92505 antibody, wu:fc17f02 antibody, zgc:112224 antibody, 123F2 antibody, NORE2A antibody, RASSF1A antibody, RDA32 antibody, REH3P21 antibody, AA536941 antibody, AU044980 antibody, Rassf1A antibody, Rassf1B antibody, Rassf1C antibody, NPR2-like, GATOR1 complex subunit antibody, Ras association (RalGDS/AF-6) domain family 1 antibody, Ras association domain family member 1 antibody, putative rassf1 antibody, Ras association domain family member 1 L homeolog antibody, Ras association (RalGDS/AF-6) domain family member 1 antibody, NPRL2 antibody, rassf1 antibody, RASSF1 antibody, Smp_157340 antibody, rassf1.L antibody, Rassf1 antibody
    Background

    Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF1 stimulation. Isoform A interacts with CDC2, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.

    Subcellular location: Cytoplasm, Nucleus

    Synonyms: 123F2, RDA32, NORE2A, RASSF1A, REH3P21, Ras association domain-containing protein 1, RASSF1

    Gene ID
    11186
    UniProt
    Q9NS23
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