RASSF1 antibody (AA 103-132)

Catalog No. ABIN1537724

The Rabbit Polyclonal anti-RASSF1 antibody is suitable to detect RASSF1 in samples from Human and Mouse. It has been validated for WB.

Quick Overview for RASSF1 antibody (AA 103-132) (ABIN1537724)

Target: RASSF1 (Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RASSF1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB22967

Product Details anti-RASSF1 Antibody

Binding Specificity: AA 103-132

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RASSF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-132 amino acids from the Central region of human RASSF1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: RASSF1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

Target Details for RASSF1

Target: RASSF1 (Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1))

Alternative Name: RASSF1

Background: This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Molecular Weight: 39219

Gene ID: 11186

NCBI Accession: NP_001193886, NP_009113, NP_733830, NP_733831, NP_733832

UniProt: Q9NS23