PERK antibody

Catalog No. ABIN865515

The Mouse Monoclonal anti-PERK antibody (Clone 5G5) (ABIN865515) specifically detects PERK in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for PERK antibody (ABIN865515)

Target: PERK (EIF2AK3) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PERK antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 5G5

Product Details anti-PERK Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human EIF2AK3 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: WB: 1/500 - 1/2000, ELISA: Propose dilution 1/10000.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100g/100l

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for PERK

Target: PERK (EIF2AK3) (Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))

Alternative Name: EIF2AK3

Background: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. Synonyms: PAX8

Molecular Weight: 125kDa

Gene ID: 9451

Pathways: Hormone Transport, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response