TAZ antibody (AA 386-390)
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- Target See all TAZ Antibodies
- TAZ (Tafazzin (TAZ))
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Binding Specificity
- AA 386-390
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TAZ antibody is un-conjugated
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Application
- Western Blotting (WB)
- Specificity
- The antibody detects endogenous level of total TAZ protein.
- Purification
- Affinity purified
- Immunogen
- Peptide sequence around AA 386-390 (V-E-S-A-L) derived from Human TAZ. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
- Top Product
- Discover our top product TAZ Primary Antibody
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- Application Notes
- Western blotting: 1:500-1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- Target
- TAZ (Tafazzin (TAZ))
- Alternative Name
- TAZ (TAZ Products)
- Synonyms
- wu:fb39f12 antibody, zgc:91803 antibody, MGC54019 antibody, TAZ antibody, taz antibody, GB11956 antibody, Afu2g13960 antibody, BTHS antibody, CMD3A antibody, EFE antibody, EFE2 antibody, G4.5 antibody, LVNCX antibody, Taz1 antibody, 5031411C02Rik antibody, 9130012G04Rik antibody, AW107266 antibody, AW552613 antibody, tafazzin antibody, tafazzin L homeolog antibody, tafazzin homolog antibody, TAZ antibody, taz antibody, taz.L antibody, LOC550948 antibody, AFUA_2G13960 antibody, AOR_1_318014 antibody, Tsp_06712 antibody, Taz antibody
- Background
- Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
- Molecular Weight
- 49 kDa
- Gene ID
- 25937
- NCBI Accession
- NP_001161
- UniProt
- Q9GZV5
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