HNRNPA1 antibody (AA 190-194)

Catalog No. ABIN871695

Product Details anti-HNRNPA1 Antibody

Target: HNRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1 (HNRNPA1))

Binding Specificity: AA 190-194

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HNRNPA1 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: The antibody detects endogenous levels of total hnRNP A1 protein.

Purification: Affinity purified

Immunogen: Peptide sequence around AA 190-194 (S-S-S-Q-R) derived from Human hnRNP A1. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Application Details

Application Notes: Western blotting: 1:500-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for HNRNPA1

Target: HNRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1 (HNRNPA1))

Alternative Name: hnRNP A1 (HNRNPA1 Products)

Synonyms: HNRPA1 antibody, HNRPA1L3 antibody, hnRNP A1 antibody, hnRNP-A1 antibody, hnrpa1 antibody, TPT1P antibody, HNRNPA1 antibody, D15Ertd119e antibody, Hdp antibody, Hnrpa1 antibody, hnrnp-A1 antibody, ROA1 antibody, zgc:66127 antibody, heterogeneous nuclear ribonucleoprotein A1 antibody, heterogeneous nuclear ribonucleoprotein A1b antibody, Heterogeneous nuclear ribonucleoprotein A1 antibody, heterogeneous nuclear ribonucleoprotein A1 S homeolog antibody, ribonucleoprotein A1a antibody, heterogeneous nuclear ribonucleoprotein A1-like antibody, heterogeneous nuclear ribonucleoprotein A1a antibody, HNRNPA1 antibody, hnrnpa1b antibody, LOC100101226 antibody, roa1 antibody, Hnrnpa1 antibody, hnrnpa1.S antibody, hnrnpa1 antibody, LOC100359118 antibody, hnrnpa1a antibody

Background: Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a member of the hnRNP A/B family of related RNA binding proteins that bind pre-mRNA and are involved in the processing, metabolism and transport of nuclear pre-mRNA transcripts . hnRNP A1 regulates the alternative splicing of c-Src, c-H-Ras and modifies initiation of translation of the fibroblast growth factor 2 mRNA. hnRNP A1 expression level is elevated in many cancers, knockdown of hnRNP A1 leads to apoptosis in various cancer cells . Although predominantly nuclear, hnRNP A1 is continually transported from the nucleus to the cytoplasm where it disassociates from mRNA and is rapidly re-imported into the nucleus . hnRNP A1 binds to cis-acting repressive sequences (CRS) of HIV-1 to influence HIV-1 production . HIV-1 enhances hnRNP A1 expression and promotes the relocalization of hnRNP A1 to the cytoplasm ,

Molecular Weight: 39 kDa

Gene ID: 3178

NCBI Accession: NP_002127

UniProt: P09651