ASXL1 antibody

Catalog No. ABIN930987

The Mouse Monoclonal anti-ASXL1 antibody (Clone 2049C2a) (ABIN930987) specifically detects ASXL1 in DB. The antibody is reactive with Human samples.

Quick Overview for ASXL1 antibody (ABIN930987)

Target: ASXL1 (Additional Sex Combs Like 1 (ASXL1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ASXL1 antibody is un-conjugated

Application: Dot Blot (DB)

Clone: 2049C2a

Product Details anti-ASXL1 Antibody

Cross-Reactivity: Human

Cross-Reactivity (Details): Other species not studied.

Purification: Protein G affinity chromatography

Immunogen: ASXL1 antibody was raised in mouse using recombinant Human Additional Sex Combs Like 1 (Drosophila) (Asxl1)

Isotype: IgG1

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: Lot specific

Buffer: ASXL1 antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1 % bovine serum albumin (BSA) and 0.05 % sodium azide (NaN3 ).

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2-8 °C for up to one year. We recommend long term storage at -20 °C.

Target Details for ASXL1

Target: ASXL1 (Additional Sex Combs Like 1 (ASXL1))

Alternative Name: ASXL1

Background: This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. Synonyms: Monoclonal ASXL1 antibody, Anti-ASXL1 antibody, Additional sex combs like 1 antibody, KIAA0978 antibody, MGC71111 antibody, MGC117280 antibody.

Pathways: Retinoic Acid Receptor Signaling Pathway