B-Cell Linker antibody (AA 171-356)

Catalog No. ABIN94495

Product Details anti-B-Cell Linker Antibody

Target: B-Cell Linker (BLNK)

Binding Specificity: AA 171-356

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This B-Cell Linker antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: The polyclonal antibody reacts with mouse SLP65 / BLNK, a cytosolic adaptor protein identified as two phosphoproteins migrating at 68 and 70 kDa in SDS/PAGE (alternatively spliced forms of human SLP65).

Cross-Reactivity (Details): Mouse

Purification: Purified by protein-A affinity chromatography.

Purity: > 95 % (by SDS-PAGE)

Immunogen: A fusion protein representing amino acids 171-356 of human BLNK.

Application Details

Application Notes: Western blotting: Reducing conditions.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for B-Cell Linker

Target: B-Cell Linker (BLNK)

Alternative Name: SLP65 / BLNK (BLNK Products)

Synonyms: BLNK antibody, blnk antibody, MGC147045 antibody, BASH antibody, Bca antibody, Ly-57 antibody, Ly57 antibody, Lyw-57 antibody, SLP-65 antibody, AGM4 antibody, BLNK-S antibody, LY57 antibody, SLP65 antibody, bca antibody, B-cell linker antibody, B cell linker antibody, BLNK antibody, blnk antibody, Blnk antibody

Background: B cell linkerprovided,SLP65 / BLNK (SH2 domain-containing leukocyte-specific phosphoprotein of 65 kDa, B cell linker protein), also known as BASH, is an adaptor protein that plays key role in B cell activation initiated by cross-linking the B cell receptor (BCR). Phosphorylated by Syk tyrosine kinase, SLP65 serves as a scaffold for Btk tyrosine kinase, Vav1 guanine nucleotide exchange factor, phospholipase C gamma2, as well as Grb2 and Nck adaptor proteins, thus represents a central linker protein that bridges the BCR-associated kinases with a multitude of signaling pathways.,SLP65, BASH, Ly57

Gene ID: 29760

UniProt: Q8WV28

Pathways: BCR Signaling