Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) (AA 284-314), (Middle Region) antibody

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Antigen
  • MGC81883
  • 11-HSD2
  • AME
  • AME1
  • HSD11K
  • HSD2
  • SDR9C3
  • 11HSD2
  • HSD11B2
  • hydroxysteroid (11-beta) dehydrogenase 2
  • hydroxysteroid 11-beta dehydrogenase 2
  • NAD-dependent 11-beta-hydroxysteroid dehydrogenase
  • hsd11b2
  • HSD11B2
  • Hsd11b2
  • HSD11K
Alternatives
anti-Human Hydroxysteroid (11-Beta) Dehydrogenase 2 antibody for ELISA
Epitope
AA 284-314, Middle Region
15
15
10
10
10
8
8
8
7
5
4
2
1
1
Reactivity
Human
87
58
52
2
2
2
2
1
1
1
1
1
1
1
Host
Rabbit
90
4
2
1
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
69
32
26
26
18
16
4
3
1
Options
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Immunogen KLH conjugated synthetic peptide between 284~314 amino acids from the Central region of human HSD11B2.
Isotype Ig
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification This antibody is purified through a protein A column; followed by peptide affinity purification.
Alternative Name 11-beta HSD2 / HSD11B2 (HSD11B2 Antibody Abstract)
Background There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.Synonyms: 11-DH2, 11-beta-hydroxysteroid dehydrogenase 2, Corticosteroid 11-beta-dehydrogenase isozyme 2, HSD11K, NAD-dependent 11-beta-hydroxysteroid dehydrogenase
Gene ID 3291
NCBI Accession NP_000187
Pathways Steroid Hormone Biosynthesis, Regulation of Systemic Arterial Blood Pressure by Hormones
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Flow Cytometry (FACS) image for anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) (AA 284-314), (Middle Region) antibody (ABIN950176) HSD11B2 flow cytometric analysis of MCF-7 cells (bottom histogram) compared to a nega...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) (AA 284-314), (Middle Region) antibody (ABIN950176) HSD11B2IHC analysis in formalin fixed and paraffin embedded skeletal muscle followed ...
Western Blotting (WB) image for anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) (AA 284-314), (Middle Region) antibody (ABIN950176) Western blot analysis of HSD11B2 in MCF-7 cell line lysates (35ug/lane). HSD11B2 (arr...
Background publications Mericq, Medina, Kakarieka, Márquez, Johnson, Iñiguez: "Differences in expression and activity of 11beta-hydroxysteroid dehydrogenase type 1 and 2 in human placentas of term pregnancies according to birth weight and gender." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 161, Issue 3, pp. 419-25, 2009 (PubMed).