AHCY antibody (Adenosylhomocysteinase) (AA 86-118)

Details for Product anti-AHCY Antibody No. ABIN950286, Supplier: Log in to see
Antigen
  • sahh
  • PSPTO5068
  • Ahcy
  • SAHH
  • adoHcyase
  • ahcy
  • AA987153
  • AL024110
  • CuBP
  • D150
  • cb1079
  • hm:zeh1173
  • hm:zeh1364
  • wu:fj67b02
  • adenosylhomocysteinase
  • Adenosylhomocysteinase
  • S-adenosylhomocysteine hydrolase
  • AHCY
  • ahcy
  • ahcY
  • Mmah_0523
  • Srot_2217
  • Ndas_3755
  • Deba_0936
  • Palpr_2392
  • Calni_0569
  • LOC100282150
  • Intca_2510
  • Marky_0392
  • Desac_1394
  • Tc00.1047053511229.50
  • Tc00.1047053511589.200
  • Tb11.01.1350
  • LmjF36.3910
  • MCYG_06244
  • Ahcy
  • ahcy-b
Epitope
AA 86-118, N-Term
20
13
10
8
4
3
3
2
2
1
1
Reactivity
Human, Mouse (Murine)
105
42
33
4
3
3
3
3
3
2
2
2
1
1
1
1
Host
Rabbit
92
17
Clonality
Polyclonal
Conjugate
This AHCY antibody is un-conjugated
8
8
7
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
79
34
22
15
13
8
7
6
4
2
1
1
Options
Supplier
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Immunogen KLH conjugated synthetic peptide between 86-118 amino acids from the N-terminal region of human AHCY
Isotype Ig
Specificity This antibody reacts to AdoHcyase.
Cross-Reactivity (Details) Species reactivity (tested):Mouse.
Purification Saturated Ammonium Sulfate (SAS) precipitation
Alternative Name AdoHcyase (AHCY) (AHCY Antibody Abstract)
Background S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.Synonyms: Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, SAHH
Gene ID 191
NCBI Accession NP_000678
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-AHCY antibody (Adenosylhomocysteinase) (AA 86-118) (ABIN950286) AHCY Antibody (N-term) flow cytometric analysis of K562 cells (right histogram) compa...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-AHCY antibody (Adenosylhomocysteinase) (AA 86-118) (ABIN950286) AHCY Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin e...
Western Blotting (WB) image for anti-AHCY antibody (Adenosylhomocysteinase) (AA 86-118) (ABIN950286) AHCY Antibody (N-term) western blot analysis in mouse liver tissue lysates (35 µg/lan...
Background publications Giusti, Saracini, Bolli, Magi, Martinelli, Peyvandi, Rasura, Volpe, Lotta, Rubattu, Mannucci, Abbate: "Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism." in: Thrombosis and haemostasis, Vol. 104, Issue 2, pp. 231-42, 2010 (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Levine, Figueiredo, Lee, Conti, Kennedy, Duggan, Poynter, Campbell, Newcomb, Martinez, Hopper, Le Marchand, Baron, Limburg, Ulrich, Haile: "A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 7, pp. 1812-21, 2010 (PubMed).

Joyce, Donald, Elder: "Individual differences in plasma cortisol changes during mania and depression." in: Journal of affective disorders, Vol. 12, Issue 1, pp. 1-5, 1987 (PubMed).